RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. [5]

RASGRF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IJE
Identifiers
Aliases	RASGRF1, CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1, Ras protein specific guanine nucleotide releasing factor 1
External IDs	OMIM: 606600 MGI: 99694 HomoloGene: 74972 GeneCards: RASGRF1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.1 Start 78,959,947 bp[1] End 79,090,773 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.1|9 47.31 cM Start 89,909,908 bp[2] End 90,026,977 bp[2]
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • glutamate receptor binding • Ras guanyl-nucleotide exchange factor activity Cellular component • cytosol • growth cone • neuron projection • cell membrane Biological process • GO:0007243 intracellular signal transduction • MAPK cascade • regulation of Rho protein signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • signal transduction • regulation of Rac protein signal transduction • regulation of synaptic plasticity • long-term memory • regulation of Ras protein signal transduction • regulation of neuronal synaptic plasticity • neuron projection development • regulation of NMDA receptor activity • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • cellular proliferation • small GTPase mediated signal transduction • positive regulation of Ras protein signal transduction • response to endoplasmic reticulum stress Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5923	19417
Ensembl	ENSG00000058335	ENSMUSG00000032356
UniProt	Q13972	P27671
RefSeq (mRNA)	NM_001145648 NM_002891 NM_153815	NM_001039655 NM_011245 NM_001357743 NM_001357744
RefSeq (protein)	NP_001139120 NP_002882 NP_722522	NP_001034744 NP_035375 NP_001344672 NP_001344673
Location (UCSC)	Chr 15: 78.96 – 79.09 Mb	Chr 9: 89.91 – 90.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.

The studies of the similar gene in mice suggested that the Ras-GEF activity of this protein in the brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].