RBM14

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene.[5][6]

RBM14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRBM14, COAA, PSP2, SIP, SYTIP1, TMEM137, RNA binding motif protein 14
External IDsOMIM: 612409 MGI: 1929092 HomoloGene: 4614 GeneCards: RBM14
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.2Start66,616,582 bp[1]
End66,627,347 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10432

56275

Ensembl

ENSG00000239306

ENSMUSG00000006456

UniProt

Q96PK6

Q8C2Q3

RefSeq (mRNA)

NM_032886
NM_001198836
NM_001198837
NM_006328

NM_019869

RefSeq (protein)

NP_001185765
NP_001185766
NP_006319

NP_063922

Location (UCSC)Chr 11: 66.62 – 66.63 MbChr 19: 4.8 – 4.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RBM14 has been shown to interact with TARBP2.[7]

Model organisms

Model organisms have been used in the study of RBM14 function. A conditional knockout mouse line called Rbm14tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[8] Male and female animals underwent a standardized phenotypic screen[9] to determine the effects of deletion.[10][11][12][13] Additional screens performed: - In-depth immunological phenotyping[14]

References

  1. GRCh38: Ensembl release 89: ENSG00000239306 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000006456 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (Sep 1997). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Human Molecular Genetics. 6 (9): 1559–64. doi:10.1093/hmg/6.9.1559. PMID 9285794.
  6. "Entrez Gene: RBM14 RNA binding motif protein 14".
  7. Iwasaki T, Chin WW, Ko L (Sep 2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". The Journal of Biological Chemistry. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
  8. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  9. "International Mouse Phenotyping Consortium".
  10. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  11. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  12. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  13. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  14. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.