RBM3

Function

This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]

RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects.[6] According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues[7] and based on confocal microscopy mainly localised to the nucleoplasm.[8]

Clinical significance

RBM3 is a proto-oncogene that is associated with tumor progression and metastasis and is a potential cancer biomarker.[6] Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable prognostic biomarker in colorectal cancer.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000102317 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Derry JM, Kerns JA, Francke U (December 1995). "RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain". Human Molecular Genetics. 4 (12): 2307–11. doi:10.1093/hmg/4.12.2307. PMID 8634703.
  5. "Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3".
  6. Zhou RB, Lu XL, Zhang CY, Yin DC (March 2017). "RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection". Oncotarget. 8 (13): 22235–22250. doi:10.18632/oncotarget.14755. PMC 5400660. PMID 28118608.
  7. "Tissue expression of RBM3 - Summary". The Human Protein Atlas.
  8. "Cell atlas - RBM3". The Human Protein Atlas.
  9. "Expression of RBM3 in cancer - Summary". The Human Protein Atlas.

Further reading

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