RBP1

Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene.[5][6][7]

RBP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRBP1, CRABP-I, CRBP, CCRBPI, RBPC, retinol binding protein 1
External IDsOMIM: 180260 MGI: 97876 HomoloGene: 2175 GeneCards: RBP1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q23Start139,517,434 bp[1]
End139,539,829 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5947

19659

Ensembl

ENSG00000114115

ENSMUSG00000046402

UniProt

P09455

Q00915

RefSeq (mRNA)

NM_002899
NM_001130992
NM_001130993
NM_001365940

NM_011254

RefSeq (protein)

NP_001124464
NP_001124465
NP_002890
NP_001352869

NP_035384

Location (UCSC)Chr 3: 139.52 – 139.54 MbChr 9: 98.42 – 98.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.[5]

Clinical significance

Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiative state of endometrial cells through the regulation of bioavailability of retinol. On the converse, loss of CRBP-1 is associated with development of endometrial cancer.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000114115 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000046402 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RBP1 retinol binding protein 1, cellular".
  6. Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ (September 1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. PMID 1654334.
  7. De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L (1998). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 226–7. doi:10.1159/000015107. PMID 9858824. S2CID 46851294.
  8. Orlandi A, Ferlosio A, Ciucci A, Francesconi A, Lifschitz-Mercer B, Gabbiani G, Spagnoli LG, Czernobilsky B (June 2006). "Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications". Mod. Pathol. 19 (6): 797–803. doi:10.1038/modpathol.3800586. PMID 16575402.

Further reading


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