RBP2

Retinol-binding protein 2 (RBP2) is a protein that in humans is encoded by the RBP2 gene.[5][6][7]

RBP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRBP2, CRABP-II, CCRBPII, RBPC2, retinol binding protein 2
External IDsOMIM: 180280 MGI: 97877 HomoloGene: 3070 GeneCards: RBP2
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q23Start139,452,884 bp[1]
End139,480,747 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5948

19660

Ensembl

ENSG00000114113

ENSMUSG00000032454

UniProt

P50120

Q08652

RefSeq (mRNA)

NM_004164

NM_009034

RefSeq (protein)

NP_004155

NP_033060

Location (UCSC)Chr 3: 139.45 – 139.48 MbChr 9: 98.49 – 98.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000114113 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032454 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP (Oct 1995). "Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle". Hum Reprod. 10 (5): 1297–304. doi:10.1093/oxfordjournals.humrep.a136137. PMID 7657783.
  6. De Baere E, Speleman F, Van Roy N, Mortier K, De Paepe A, Messiaen L (Mar 1999). "Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 240–1. doi:10.1159/000015191. PMID 10072590. S2CID 22941923.
  7. "Entrez Gene: RBP2 retinol binding protein 2, cellular".

Further reading


  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Retinol-binding protein 2 (RBP2)



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