RBPMS

RNA-binding protein with multiple splicing is a protein that in humans is encoded by the RBPMS gene.[5][6]

RBPMS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRBPMS, HERMES, RNA binding protein with multiple splicing, RNA binding protein, mRNA processing factor
External IDsOMIM: 601558 MGI: 1334446 HomoloGene: 38238 GeneCards: RBPMS
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p12Start30,384,511 bp[1]
End30,572,256 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11030

19663

Ensembl

ENSG00000157110

ENSMUSG00000031586

UniProt

Q93062

Q9WVB0

RefSeq (mRNA)

NM_001008710
NM_001008711
NM_001008712
NM_006867

NM_001042674
NM_001042675
NM_001286168
NM_019733

RefSeq (protein)

NP_001008710
NP_001008711
NP_001008712
NP_006858

NP_001036139
NP_001036140
NP_001273097
NP_062707

Location (UCSC)Chr 8: 30.38 – 30.57 MbChr 8: 33.78 – 33.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in length and family members contain one to four copies of the domain. The RRM domain consists of two short stretches of conserved sequence called RNP1 and RNP2, as well as a few highly conserved hydrophobic residues. The protein encoded by this gene has a single, putative RRM domain in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]

It is uniquely expressed in retinal ganglion cells in the mammalian retina,[7] for reasons unknown.

Interactions

RBPMS has been shown to interact with SMUG1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000157110 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031586 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shimamoto A, Kitao S, Ichikawa K, Suzuki N, Yamabe Y, Imamura O, Tokutake Y, Satoh M, Matsumoto T, Kuromitsu J, Kataoka H, Sugawara K, Sugawara M, Sugimoto M, Goto M, Furuichi Y (Nov 1996). "A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10913–7. doi:10.1073/pnas.93.20.10913. PMC 38257. PMID 8855282.
  6. "Entrez Gene: RBPMS RNA binding protein with multiple splicing".
  7. Rodriguez AR, de Sevilla Müller LP, Brecha NC (Mar 2014). "The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina". J. Comp. Neurol. 522 (6): 1411–43. doi:10.1002/cne.23521. PMC 3959221. PMID 24318667.
  8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Hillman RT, Green RE, Brenner SE (2004). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.


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