RGL2

RGL2
Identifiers
Aliases	RGL2, HKE1.5, KE1.5, RAB2L, ral guanine nucleotide dissociation stimulator like 2
External IDs	OMIM: 602306 MGI: 107483 HomoloGene: 3494 GeneCards: RGL2
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	33,298,942 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	33,937,687 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• Ras guanyl-nucleotide exchange factor activity; • GO:0001948 protein binding; • guanyl-nucleotide exchange factor activity; • Rho guanyl-nucleotide exchange factor activity;
Cellular component	• intracellular; • cellular component;
Biological process	• small GTPase mediated signal transduction; • Ras protein signal transduction; • signal transduction; • negative regulation of cardiac muscle cell apoptotic process; • regulation of Ral protein signal transduction; • positive regulation of phosphatidylinositol 3-kinase signaling; • regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	5863
	19732
ENSG00000228736; ENSG00000237441; ENSG00000237825; ENSG00000224841; ENSG00000206282;
	n/a
	ENSMUSG00000041354
	O15211
	Q61193
	NM_001243738; NM_004761
	NM_009059
	NP_001230667; NP_004752
	NP_033085
	Wikidata
View/Edit Human	View/Edit Mouse

Ral guanine nucleotide dissociation stimulator-like 2 is a protein that in humans is encoded by the RGL2 gene.[5][6]

Interactions

RGL2 has been shown to interact with HRAS.[7][8]

References

ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 GRCh38: Ensembl release 89: ENSG00000228736, ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041354 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (January 1997). "Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS". Cytogenet Cell Genet. 74 (4): 263–5. doi:10.1159/000134431. PMID 8976381.
"Entrez Gene: RGL2 ral guanine nucleotide dissociation stimulator-like 2".
Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (November 1996). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. 271 (47): 29903–8. doi:10.1074/jbc.271.47.29903. PMID 8939933.

Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (1997). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. 271 (47): 29903–8. doi:10.1074/jbc.271.47.29903. PMID 8939933.
Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S, Trowsdale J (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC". Eur. J. Immunol. 28 (2): 459–67. doi:10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z. PMID 9521053.
Herberg JA, Beck S, Trowsdale J (1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J. Mol. Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
Ando A, Kikuti YY, Abe K, Shigenari A, Kawata H, Ikemura T, Kimura M, Inoko H (1999). "cDNA cloning, northern hybridization, and mapping analysis of a putative GDS-related protein gene at the centromeric ends of the human and mouse MHC regions". Immunogenetics. 49 (4): 354–6. doi:10.1007/s002510050504. PMID 10079301. S2CID 30077097.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 GRCh38: Ensembl release 89: ENSG00000228736, ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041354 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8976381-5] Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (January 1997). "Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS". Cytogenet Cell Genet. 74 (4): 263–5. doi:10.1159/000134431. PMID 8976381.

[entrez-6] "Entrez Gene: RGL2 ral guanine nucleotide dissociation stimulator-like 2".

[pmid15031288-7] Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.

[pmid8939933-8] Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (November 1996). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. 271 (47): 29903–8. doi:10.1074/jbc.271.47.29903. PMID 8939933.

RGL2

Interactions

References

Further reading