RGS20

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.[5][6][7]

RGS20
Identifiers
AliasesRGS20, RGSZ1, ZGAP1, g(z)GAP, gz-GAP, regulator of G-protein signaling 20, regulator of G protein signaling 20
External IDsOMIM: 607193 MGI: 1929866 HomoloGene: 2745 GeneCards: RGS20
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q11.23Start53,851,795 bp[1]
End53,959,303 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8601

58175

Ensembl

ENSG00000147509

ENSMUSG00000002459

UniProt

O76081

Q9QZB1

RefSeq (mRNA)

NM_001286673
NM_001286674
NM_001286675
NM_003702
NM_170587

NM_001177795
NM_001290372
NM_021374

RefSeq (protein)

NP_001273602
NP_001273603
NP_001273604
NP_003693
NP_733466

NP_001171266
NP_001277301
NP_067349

Location (UCSC)Chr 8: 53.85 – 53.96 MbChr 1: 4.91 – 5.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM][7]

In melanocytic cells RGS20 gene expression may be regulated by MITF.[8]

Interactions

RGS20 has been shown to interact with GNAO1[9] and GNAZ.[5][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000147509 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002459 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Glick JL, Meigs TE, Miron A, Casey PJ (October 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". The Journal of Biological Chemistry. 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. PMID 9748279.
  6. Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (October 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". The Journal of Biological Chemistry. 273 (40): 26014–25. doi:10.1074/jbc.273.40.26014. PMID 9748280.
  7. "Entrez Gene: RGS20 regulator of G-protein signalling 20".
  8. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  9. Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R (June 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cellular Signalling. 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. PMC 3107604. PMID 18407463.
  10. Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". Journal of Cell Science. 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. PMID 12414994.

Further reading


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