RHOBTB3

RHOBTB3
Identifiers
Aliases	RHOBTB3, Rho related BTB domain containing 3
External IDs	OMIM: 607353 MGI: 1920546 HomoloGene: 8932 GeneCards: RHOBTB3
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	95,824,383 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	75,943,925 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • Rab GTPase binding; • GO:0001948 protein binding; • hydrolase activity; • ATP binding; • ATPase activity; • GTPase activity; • GTP binding; • protein kinase binding;
Cellular component	• cytoplasm; • Golgi apparatus; • extracellular exosome; • cytosol; • trans-Golgi network membrane; • cell membrane; • cell cortex; • cell projection;
Biological process	• retrograde transport, endosome to Golgi; • vesicle-mediated transport; • male gonad development; • transport; • actin filament organization; • establishment or maintenance of cell polarity; • Rho protein signal transduction; • regulation of cell shape; • actin cytoskeleton organization; • regulation of actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	22836
	73296
	ENSG00000164292
	ENSMUSG00000021589
	O94955
	Q9CTN4
	NM_014899
	NM_028493
	NP_055714
	NP_082769
	Wikidata
View/Edit Human	View/Edit Mouse

Rho-related BTB domain-containing protein 3 is a protein that in humans is encoded by the RHOBTB3 gene.[5][6][7]

Function

RHOBTB3 is a member of the evolutionarily conserved RhoBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM][7]

Model organisms

*Rhobtb3* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Abnormal[8]
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Abnormal[9]
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Abnormal[10]
Radiography	Abnormal[11]
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Citrobacter infection	Normal[12]
All tests and analysis from[13][14]

Model organisms have been used in the study of RHOBTB3 function. A conditional knockout mouse line, called Rhobtb3^{tm1a(KOMP)Wtsi}[15][16] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[17][18][19]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[13][20] Twenty three tests were carried out on mutant mice and four significant abnormalities were observed.[13] Homozygote mutant males had a decreased body weight and abnormal tooth morphology; females had decreased forepaw grip strength and both sexes had a decreased body length.[13]

References

GRCh38: Ensembl release 89: ENSG00000164292 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021589 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Rivero F, Dislich H, Glöckner G, Noegel AA (Mar 2001). "The Dictyostelium discoideum family of Rho-related proteins". Nucleic Acids Research. 29 (5): 1068–79. doi:10.1093/nar/29.5.1068. PMC 29714. PMID 11222756.
Boureux A, Vignal E, Faure S, Fort P (Jan 2007). "Evolution of the Rho family of ras-like GTPases in eukaryotes". Molecular Biology and Evolution. 24 (1): 203–16. doi:10.1093/molbev/msl145. PMC 2665304. PMID 17035353.
"Entrez Gene: RHOBTB3 Rho-related BTB domain containing 3".
"Body weight data for Rhobtb3". Wellcome Trust Sanger Institute.
"Grip strength data for Rhobtb3". Wellcome Trust Sanger Institute.
"DEXA data for Rhobtb3". Wellcome Trust Sanger Institute.
"Radiography data for Rhobtb3". Wellcome Trust Sanger Institute.
"Citrobacter infection data for Rhobtb3". Wellcome Trust Sanger Institute.
Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
Mouse Resources Portal, Wellcome Trust Sanger Institute.
"International Knockout Mouse Consortium".
"Mouse Genome Informatics".
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Ramos S, Khademi F, Somesh BP, Rivero F (Oct 2002). "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse". Gene. 298 (2): 147–57. doi:10.1016/S0378-1119(02)00980-0. PMID 12426103.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164292 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021589 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11222756-5] Rivero F, Dislich H, Glöckner G, Noegel AA (Mar 2001). "The Dictyostelium discoideum family of Rho-related proteins". Nucleic Acids Research. 29 (5): 1068–79. doi:10.1093/nar/29.5.1068. PMC 29714. PMID 11222756.

[pmid17035353-6] Boureux A, Vignal E, Faure S, Fort P (Jan 2007). "Evolution of the Rho family of ras-like GTPases in eukaryotes". Molecular Biology and Evolution. 24 (1): 203–16. doi:10.1093/molbev/msl145. PMC 2665304. PMID 17035353.

[entrez-7] "Entrez Gene: RHOBTB3 Rho-related BTB domain containing 3".

[Body_weight-8] "Body weight data for Rhobtb3". Wellcome Trust Sanger Institute.

[Grip_strength-9] "Grip strength data for Rhobtb3". Wellcome Trust Sanger Institute.

[DEXA-10] "DEXA data for Rhobtb3". Wellcome Trust Sanger Institute.

[Radiography-11] "Radiography data for Rhobtb3". Wellcome Trust Sanger Institute.

[''Citrobacter''_infection-12] "Citrobacter infection data for Rhobtb3". Wellcome Trust Sanger Institute.

[mgp_reference-13] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.

[14] Mouse Resources Portal, Wellcome Trust Sanger Institute.

[allele_ref-15] "International Knockout Mouse Consortium".

[mgi_allele_ref-16] "Mouse Genome Informatics".

[pmid21677750-17] Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-18] Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-19] Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.

[pmid21722353-20] van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

RHOBTB3

Function

Model organisms

References

Further reading