RIKEN Quantitative Biology Center

The Quantitative Biology Center (QBiC) is a Strategic Research Center[1] of the Japanese national research and development institute,[2] Riken. In November 2014, they succeeded in making a translucent mouse in order to see its internal organs more clearly.[3]

Overview

QBiC is a systems biology research center. The center is led by director Toshio Yanagida and is divided into three research cores.[4]

  • Cell Dynamics Research Core
  • Computational Biology Research Core
  • Cell Design Research Core

Research Cores

Cell Dynamics Research Core

The Cell Dynamics Research Core houses the Laboratory for Cell Polarity Regulation, led by Yasushi Okada. Okada reported the first visualization of Mitochondrial Derived Vesicles (MDV) from mitochondrial protrusions using ultrafast super-resolution fluorescence imaging with spinning disk confocal microscope optics.[5] This core also includes Shuichi Onami's Laboratory for Developmental Dynamics creator of the Biological Dynamics Markup Language (BDML). The Onami lab hosts the Systems Science of Biological Dynamics (SSBD) database.

Computational Biology Research Core

The Computational Biology Research Core is a user of the K computer and developer of the MDGRAPE-4 supercomputer.

Cell Design Research Core

The Cell Design Research Core houses the Laboratory for Synthetic Biology which reported the see-through mouse.[6] This core is also notable for housing Yoshihiro Shimizu's Laboratory for Cell-Free Protein Synthesis, developer of the PURE cell free protein expression system.[7][8] Yo Takana's Laboratory for Integrated Biodevice, which created a battery from the electric organ of a torpedo ray.[9]

References
  1. "Riken Centers & Labs". Retrieved 9 November 2015.
  2. "About Riken". Retrieved 9 November 2015.
  3. Kaszor, Daniel (November 7, 2014). "Japanese scientists use remarkable new technique to make mice nearly invisible (or at least translucent)". National Post. Retrieved 9 November 2015.
  4. "QBiC Overview". Retrieved 9 November 2015.
  5. Hayashi, S; Okada, Y (2015). "Ultrafast superresolution fluorescence imaging with spinning disk confocal microscope optics". Mol. Biol. Cell. 26 (9): 1743–1751. doi:10.1091/mbc.E14-08-1287. PMC 4436784. PMID 25717185.
  6. Tainaka, K; Kubota, SI; Suyama, TQ; Susaki, EA; Perrin, D; Ukai-Tadenuma, M; Ukai, H; Ueda, HR (2014-11-06). "Whole-Body Imaging with Single-Cell Resolution by Tissue Decolorization". Cell. 159 (4): 911–924. doi:10.1016/j.cell.2014.10.034. PMID 25417165.
  7. Shimizu, Yoshihiro; Inoue, Akio; Tomari, Yukihide; Suzuki, Tsutomu; Yokogawa, Takashi; Nishikawa, Kazuya; Ueda, Takuya (2001). "Nature Citation". Nature Biotechnology. 19 (8): 751–755. doi:10.1038/90802. PMID 11479568.
  8. Shimizu, Y.; Ueda, T. (2010-01-01). "PURE Technology". In Endo, Yaeta; Takai, Kazuyuki; Ueda, Takuya (eds.). PURE Technology - Springer. Methods in Molecular Biology. 607. Humana Press. pp. 11–21. doi:10.1007/978-1-60327-331-2_2. ISBN 978-1-60327-330-5. PMID 20204844.
  9. ""Ray" of light – researchers power LED by connecting it to a fish". www.gizmag.com. Retrieved 2016-06-13.

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