RIMS2

Regulating synaptic membrane exocytosis protein 2 is a protein that in humans is encoded by the RIMS2 gene.[4][5][6]

RIMS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRIMS2, OBOE, RAB3IP3, RIM2, regulating synaptic membrane exocytosis 2
External IDsOMIM: 606630 MGI: 2152972 HomoloGene: 81639 GeneCards: RIMS2
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9699

116838

Ensembl

ENSG00000176406

ENSMUSG00000037386

UniProt

Q9UQ26

Q9EQZ7

RefSeq (mRNA)

NM_001100117
NM_001282881
NM_001282882
NM_014677

NM_001256382
NM_001256383
NM_001256384
NM_053271

RefSeq (protein)

NP_001243311
NP_001243312
NP_001243313
NP_444501

Location (UCSC)n/aChr 15: 39.2 – 39.68 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

RIMS2 has been shown to interact with YWHAH,[7] RAPGEF4,[8][9] and UNC13A.[10]

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000037386 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  5. Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J Biol Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
  6. "Entrez Gene: RIMS2 regulating synaptic membrane exocytosis 2".
  7. Sun, Lei; Bittner Mary A; Holz Ronald W (October 2003). "Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus". J. Biol. Chem. United States. 278 (40): 38301–9. doi:10.1074/jbc.M212801200. ISSN 0021-9258. PMID 12871946.
  8. Shibasaki, Tadao; Sunaga Yasuhiro; Fujimoto Kei; Kashima Yasushige; Seino Susumu (February 2004). "Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis". J. Biol. Chem. United States. 279 (9): 7956–61. doi:10.1074/jbc.M309068200. ISSN 0021-9258. PMID 14660679.
  9. Kashima, Y; Miki T; Shibasaki T; Ozaki N; Miyazaki M; Yano H; Seino S (Dec 2001). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion". J. Biol. Chem. United States. 276 (49): 46046–53. doi:10.1074/jbc.M108378200. ISSN 0021-9258. PMID 11598134.
  10. "Protein unc-13 homolog A". UniProt.

Further reading


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