RIPK2

Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.[5][6][7]

RIPK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRIPK2, CARD3, CARDIAK, CCK, GIG30, RICK, RIP2, receptor interacting serine/threonine kinase 2
External IDsOMIM: 603455 MGI: 1891456 HomoloGene: 37856 GeneCards: RIPK2
EC number2.7.10.2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q21.3Start89,757,806 bp[1]
End89,791,064 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8767

192656

Ensembl

ENSG00000104312

ENSMUSG00000041135

UniProt

O43353

P58801

RefSeq (mRNA)

NM_003821
NM_001375360

NM_138952
NM_001329751

RefSeq (protein)

NP_003812
NP_001362289

NP_001316680
NP_620402

Location (UCSC)Chr 8: 89.76 – 89.79 MbChr 4: 16.12 – 16.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli.[7]

Interactions

RIPK2 has been shown to interact with BIRC2.[6][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000104312 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041135 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Inohara N, del Peso L, Koseki T, Chen S, Nunez G (Jun 1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis". J Biol Chem. 273 (20): 12296–300. doi:10.1074/jbc.273.20.12296. PMID 9575181.
  6. Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (Nov 1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr Biol. 8 (15): 885–8. doi:10.1016/S0960-9822(07)00352-1. PMID 9705938. S2CID 1235278.
  7. "Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2".
  8. McCarthy, J V; Ni J; Dixit V M (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. UNITED STATES. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. ISSN 0021-9258. PMID 9642260.

Further reading


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