RMI1

RecQ-mediated genome instability protein 1 is a protein that in humans is encoded by the RMI1 gene.[5][6]

RMI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRMI1, BLAP75, C9orf76, FAAP75, RecQ mediated genome instability 1
External IDsOMIM: 610404 MGI: 1921636 HomoloGene: 41601 GeneCards: RMI1
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q21.32Start83,980,711 bp[1]
End84,004,074 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80010

74386

Ensembl

ENSG00000178966

ENSMUSG00000035367

UniProt

Q9H9A7

Q9D4G9

RefSeq (mRNA)

NM_024945
NM_001358291
NM_001358292
NM_001358293
NM_001358294

NM_001168248
NM_028904

RefSeq (protein)

NP_079221
NP_001345220
NP_001345221
NP_001345222
NP_001345223

NP_001161720
NP_083180

Location (UCSC)Chr 9: 83.98 – 84 MbChr 13: 58.4 – 58.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Meiosis

During meiosis in budding yeast Saccharomyces cerevisiae, TOP3 (a type I topoisomerase) and its accessory factor RMI1 form a heterodimer that functions to allow passage of one DNA single strand through another. The TOP3-RMI1 heterodimer associates with Sgs1 (Bloom helicase ortholog) to form a complex that catalyzes dissolution of double Holliday junctions.[7] Furthermore, the TOP3-RMI1 heterodimer participates in all meiotic recombination functions associated with Sgs1, most significantly as an early recombination intermediate chaperone, promoting regulated crossover and non-crossover recombination and preventing accumulation of aberrant recombination intermediates.[8] In particular, the TOP3-RMI1–SGS1 complex promotes early formation of non-crossover recombinants during meiosis.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000178966 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035367 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yin J, Sobeck A, Xu C, Meetei AR, Hoatlin M, Li L, Wang W (May 2005). "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity". EMBO J. 24 (7): 1465–76. doi:10.1038/sj.emboj.7600622. PMC 1142546. PMID 15775963.
  6. "Entrez Gene: RMI1 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)".
  7. Bizard AH, Hickson ID (2014). "The dissolution of double Holliday junctions". Cold Spring Harb Perspect Biol. 6 (7): a016477. doi:10.1101/cshperspect.a016477. PMC 4067992. PMID 24984776.
  8. Kaur H, De Muyt A, Lichten M (2015). "Top3-Rmi1 DNA single-strand decatenase is integral to the formation and resolution of meiotic recombination intermediates". Mol. Cell. 57 (4): 583–94. doi:10.1016/j.molcel.2015.01.020. PMC 4338413. PMID 25699707.

Further reading


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