rRNA (adenine-N6-)-methyltransferase

In enzymology, a rRNA (adenine-N6-)-methyltransferase (EC 2.1.1.48) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + rRNA S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine
rRNA (adenine-N6-)-methyltransferase
Identifiers
EC number2.1.1.48
CAS number9076-81-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and rRNA, whereas its two products are S-adenosylhomocysteine and rRNA containing N6-methyladenine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase. Other names in common use include ribosomal ribonucleate adenine 6-methyltransferase, gene ksgA methyltransferase, ribonucleic acid-adenine (N6) methylase, ErmC 23S rRNA methyltransferase, and S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1QAM, 1QAN, 1QAO, 1QAQ, 1YUB, and 2ERC.

References

    • Sipe JE, Anderson WM, Remy CN, Love SH (1972). "Characterization of S-adenosylmethionine: ribosomal ribonucleic acid-adenine (N 6 -) methyltransferase of Escherichia coli strain B". J. Bacteriol. 110 (1): 81–91. doi:10.1128/JB.110.1.81-91.1972. PMC 247381. PMID 4622906.


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