Rainer Liedtke

Rainer Kurt Liedtke (16 September 1943 – 15 September 2012) was a German physician, scientist and entrepreneur who specialised in the theory and practice of biomedical information systems and medical innovation, and new therapies of pain, stress, cell degeneration.

Background

Liedtke was born September 16, 1943, in Königsberg, East Prussia, and died September 15, 2012, in Grünwald, Bavaria. Doctor's degree in medicine: Biochemical studies on DNA and RNA (Institute of physiological Chemistry, University of Bonn); Institute of Pharmacology University of Bonn; Physician at hospital for several years (i. a Women Hospital University of Bonn) and initial research, i.a. by order of the German Research Foundation; Hereafter several years pharmaceutical industry (i.a. as director of clinical research at Squibb, medical director at E. Lilly), parallel work as a university lecturer for pharmacology (i.a. University of Regensburg), invited lectures (Pharmacology) at i.a. University of Frankfurt. Company founder (i.a. American Pharmed Labs, renamed to EpiCept) and its Chairman & CEO for several years.[1] Member of various scientific associations in the areas of pharmacology, endocrinology, biological chemistry.

Inventions and medical developments

These include biomedical information systems and a number of new transdermal therapies, e.g. transdermal hormonal contraception (1988), including its first time clinical proof (together with L. Wildt, University of Erlangen).[2] Bioinformatics conception of a "transdermal therapy of neuromuscular pain" with sodium channel blockers (1993/94), including the first clinical proof of effectiveness in back pain and postoperative pain (1995) and first market product of its kind in the USA.[3] Another US product (Lidoderm) that is based on the same conception is approved for postherpetic pain. Transdermal beta-blockers, including the first time clinical proof in hypertension (with W. Vetter, University of Zurich, H. Vetter, University of Bonn, W. Zidek, University of Münster (1987) and in Angina pectoris (with J. Bonelli, F. Gazo, University of Vienna (1988). Some technical basics and an actualized synopsis of these new findings have been published in a special volume of 'Drug Research' (1989).[4] Transdermal insulin patch as an alternative to insulin injection, with a first time proof in preclinical studies (with K. Suwelack, K. Karzel, University of Bonn (1990)[5] and in type II diabetics (with M. Sorger, H. Vetter, University of Bonn (1990).[6] Antidepressive effect of oxytocin. This has been predicted with a new biocybernetics model (1998/99), hereafter these effects were also experimentally confirmed (with I. Neumann, University of Regensburg, R. Landgraf, Max-Planck-Institute, M. Ludwig, University of Edinburgh (2000);[7][8] A model of a pathogenetic cell mechanism in arteriosclerosis (2006). Current Developments. "Intelligent" medical information systems;[9] a new general theory on pain - though this was in the controversial and non-peer reviewed journal Medical Hypotheses.[10] Arterial Vascular Effects of Non-steroidal Antiphlogistic Drugs[11] – A Biochemical Model on an Intramural Induction of Arteriosclerosis (2008).

Author and writer

Scientific publications, medical specialist books, medical information for patients, more than 100 international patent applications (focus: drug therapy, information technology). Books: i.a. 'Introduction in drug therapy' (in German; with K. Karzel, University of Bonn),[12] 'Dictionary of clinical pharmacology' (in German; Editor),[13] Drugs – a translator for patients,[14] 'Pharmacology and clinical use of ACE inhibitors' (with F. Gross, University of Heidelberg), 'Relative Intelligence'. Scripts and articles on related areas (e.g. general pharmacology, biological intelligence, artificial intelligence), critical statements on new biological developments (e.g. genomics, gene food), partly also in an own medical blog.

References
  1. APL's progress on pain therapies; Scrip, World Pharmaceutical News, Issue No. 2375, October 2, 1998
  2. pharmed’s oral insulin R&D / PMT patch: Scrip, World Pharmaceutical News, No 1489, February 16, 1990 p 29: "In 10 healthy volunteers the patch suppressed ovulation".
  3. Physician introduces pain-relief patch; The Sunday Star Ledger, New Jersey, USA, June 4, 1995.
  4. R.K. Liedtke (Edit.), Transdermaltherapie mit dem Betablocker Mepindolol (Transdermal Therapy with the Beta-blocker Mepindolol), Arzneim Forsch./ Drug Research 39 (II), 11a (1989), (ISSN 0004-4172)
  5. Liedtke RK, Suwelack K, Karzel K (1990). "Effect of peroral and transdermal insulin preparations on blood glucose concentration in mice". Arzneimittel-Forschung. 40 (8): 880–3. PMID 2242079.
  6. Liedtke RK, Sorger M, Merk F, Vetter H (August 1990). "Transdermal administration of insulin in type II diabetics. Results of a clinical pilot study". Arzneimittel-Forschung. 40 (8): 884–6. PMID 2242080.
  7. I.D. Neumann, R.K. Liedtke, M. Ludwig, R. Langraf: Intranasally applied Oxytocin: Brain uptake and effects on neuronal functions and emotionality Summary in: International Society of PsychoNeuroEndocrinology (ISPNE) XXXI. Annual Meeting 2000, Melbourne
  8. R. K. Liedtke, R. Landgraf, I. D. Neumann, Intranasally applied Oxytocin: A novel route of administration? (Poster), 1st World Congress of Women's Mental Health, Berlin 2001
  9. A preliminary video introduction in the operative structure of a new internet application of a medical self-diagnosis on YouTube (in german language)
  10. Liedtke, RK (2009). "A general theory on pain as an integrated thermodynamic mechanism". Medical Hypotheses. 73 (1): 86–9. doi:10.1016/j.mehy.2009.01.026. PMID 19264417.
  11. Liedtke RK (January 2009). "A model on the induction of adverse vascular long-term effects of NSAIDs". Medicinal Chemistry. 5 (1): 23–8. doi:10.2174/157340609787049235. PMID 19149647.
  12. K. Karzel, R.K. Liedtke, Einführung in die Arzneimittelherapie (Grundlagen der allgemeinen Pharmakologie für Mediziner, Zahnmediziner und Pharmazeuten), G. Fischer Stuttgart/New York 2nd Edit. 1985, (ISBN 3-437-00425-5)
  13. R.K. Liedtke (Hsgb), Wörterbuch der Arzneimitteltherapie (Klinische Pharmakologie für Mediziner und Pharmazeuten), G. Fischer, Stuttgart-New York, 2nd Edit. 1985 (ISBN 3-437-10959-6)
  14. Drugs – a translator for patients (Kindle Edition 2011)
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