Rho gtpase activating protein 21

Rho GTPase activating protein 21 is a protein that in humans is encoded by the ARHGAP21 gene. [5]

ARHGAP21
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGAP21, ARHGAP10, Rho GTPase activating protein 21
External IDsOMIM: 609870 MGI: 1918685 HomoloGene: 10822 GeneCards: ARHGAP21
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p12.1|10p12.3Start24,583,609 bp[1]
End24,723,668 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57584

71435

Ensembl

ENSG00000107863

ENSMUSG00000036591

UniProt

Q5T5U3

Q6DFV3

RefSeq (mRNA)

NM_020824

NM_001081364
NM_001128084

RefSeq (protein)

NP_001074833
NP_001121556

Location (UCSC)Chr 10: 24.58 – 24.72 MbChr 2: 20.85 – 20.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]). There is little scientific literature on ARHGAP21, but recent reviews highlighted that it plays an important role in cytoskeletal processes in cancer, substance transport within the cell, and insulin secretion [6]

References

  1. GRCh38: Ensembl release 89: ENSG00000107863 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036591 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Rho GTPase activating protein 21". Retrieved 2017-01-30.
  6. Rosa LRO; Soares, G. M.; Silveira, L. R.; Boschero, A. C.; Barbosa-Sampaio HCL (2018). "ARHGAP21 as a master regulator of multiple cellular processes". Journal of Cellular Physiology. 233 (11): 8477–8481. doi:10.1002/jcp.26829. PMID 29856495. S2CID 46919924.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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