Ribonucleoside-triphosphate reductase

Ribonucleoside-triphosphate reductase (EC 1.17.4.2, ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with systematic name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O ribonucleoside triphosphate + thioredoxin
Ribonucleoside-triphosphate reductase
Ribonucleoside-triphosphate reductase dimer, Thermotoga maritima
Identifiers
EC number1.17.4.2
CAS number9068-66-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.

References

  1. Blakley RL (May 1965). "Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii". The Journal of Biological Chemistry. 240: 2173–80. PMID 14299643.
  2. Goulian M, Beck WS (September 1966). "Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii". The Journal of Biological Chemistry. 241 (18): 4233–42. PMID 5924645.
  3. Lammers, M.; Follmann, H. (1983). "The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation". Struct. Bonding. 54: 27–91. doi:10.1007/bfb0111318.
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