Ribosomal protein L20 leader
L20 ribosomal protein leader is a ribosomal protein leader involved in the ribosome biogenesis. It is used as an autoregulatory mechanism to control the concentration of ribosomal proteins L20. The structure is located in the 5′ untranslated regions of mRNAs encoding initiation factor 3 followed by ribosomal proteins L35 and L20 (infC-rpmI-rplT). A Rho-independent transcription terminator structure that is probably involved in regulation is included at the 3′ end. This family is a putative ribosomal protein leader autoregulatory structure[1] found in B. subtilis and other low-GC Gram-positive bacteria. A second example were predicted in Deltaproteobacteria with bioinformatic approaches. [2] In this structure were similarities between the rRNA binding site of the L20 ribosomal protein and the L20 ribosomal protein leader binding site detected.[2]
L20_leader | |
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Consensus secondary structure and sequence conservation of Ribosomal protein L20 leader | |
Identifiers | |
Symbol | L20_leader |
Rfam | RF00558 |
Other data | |
RNA type | Cis-reg; leader |
GO | GO:0010468 |
SO | SO:0000233 |
PDB structures | PDBe |
L20-Deltaproteobacteria | |
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Consensus secondary structure and sequence conservation of L20-Deltaproteobacteria ribosomal protein leader | |
Identifiers | |
Symbol | L20-Deltaproteobacteria |
Rfam | RF03126 |
Other data | |
RNA type | Cis-reg; leader |
SO | SO:0000837 |
PDB structures | PDBe |
See also
References
- Zengel JM, Lindahl L (1994). Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli. Progress in Nucleic Acid Research and Molecular Biology. 47. pp. 331–370. doi:10.1016/S0079-6603(08)60256-1. ISBN 978-0-12-540047-3. PMID 7517053.
- Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi:10.1186/s12866-020-01823-6. PMC 7247131. PMID 32448158.