Ribosomal protein L20 leader

L20 ribosomal protein leader is a ribosomal protein leader involved in the ribosome biogenesis. It is used as an autoregulatory mechanism to control the concentration of ribosomal proteins L20. The structure is located in the 5′ untranslated regions of mRNAs encoding initiation factor 3 followed by ribosomal proteins L35 and L20 (infC-rpmI-rplT). A Rho-independent transcription terminator structure that is probably involved in regulation is included at the 3′ end. This family is a putative ribosomal protein leader autoregulatory structure[1] found in B. subtilis and other low-GC Gram-positive bacteria. A second example were predicted in Deltaproteobacteria with bioinformatic approaches. [2] In this structure were similarities between the rRNA binding site of the L20 ribosomal protein and the L20 ribosomal protein leader binding site detected.[2]

L20_leader
Consensus secondary structure and sequence conservation of Ribosomal protein L20 leader
Identifiers
SymbolL20_leader
RfamRF00558
Other data
RNA type Cis-reg; leader
GOGO:0010468
SOSO:0000233
PDB structuresPDBe
L20-Deltaproteobacteria
Consensus secondary structure and sequence conservation of L20-Deltaproteobacteria ribosomal protein leader
Identifiers
SymbolL20-Deltaproteobacteria
RfamRF03126
Other data
RNA type Cis-reg; leader
SOSO:0000837
PDB structuresPDBe

See also

References

  1. Zengel JM, Lindahl L (1994). Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli. Progress in Nucleic Acid Research and Molecular Biology. 47. pp. 331–370. doi:10.1016/S0079-6603(08)60256-1. ISBN 978-0-12-540047-3. PMID 7517053.
  2. Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi:10.1186/s12866-020-01823-6. PMC 7247131. PMID 32448158.
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