Robert Harold Wasserman

Robert Harold Wasserman (11 February 1926, Schenectady, New York – 23 May 2018, Ithaca, New York) was a professor of veterinary medicine and a research scientist, known as the principal investigator leading the scientists credited with the discovery of calcium-binding proteins.[1][2]

Biography

After graduating from high school in Schenectady, Wasserman matriculated in June 1943 at Union College, where he studied for three months before joining the Army Specialized Training Program and then the U. S. Army for basic training. In October 1944 he was sent overseas, where in December 1944 his division participated in operations of the Battle of the Bulge. After military service in WWII, he spent a year working on a farm in upstate New York and then matriculated at Cornell University.[1] There he graduated with a bachelor's degree in microbiology in 1949. After a year at Michigan State University, where he graduated in August 1950 with a master's degree in microbiology,[1][3] Wasserman returned to Cornell University. There he graduated in 1953 with a Ph.D. in nutritional microbiology.[1]

From 1953 to 1957, Wasserman was employed at the University of Tennessee's Atomic Energy Commission facility, where he worked on the radiation biology program with Dr. Cyril L. Comar (1914–1979), the program's director. In spring 1958, Wasserman returned to Cornell University as an associate professor in the New York State College of Veterinary Medicine's newly created Laboratory of Radiation Biology. Comar, who had moved to Cornell, in 1957 was the Laboratory's director. Wasserman was promoted in 1963 to full professor and eventually retired from Cornell as professor emeritus.[1]

... Wasserman studied the mechanisms of mineral ion transport, focusing on the function of vitamin D on intestinal absorption of calcium and phosphorus. Wasserman would make foundational discoveries in this line of study, including the identification and characterization of calcium-binding protein, known today as calbindin.[4]

In the mid-1970s, Wasserman developed an interest in the hypercalcemic effects of extracts of the Solanum malacoxylon. This plant is common to South American countries, where calcinosis, including tissue calcification, and associated pathology, that can be lethal, occurs in grazing cattle. This calcinogenic plant was demonstrated to produce the hypercalcemic effect through production of 1,25-dihydroxyvitamin D3-glycoside. Wasserman purified this water-soluble botanical in 1976. They also identified a similar calcinogenic plant, Cestrum diurnum, that is found in the southern United States. They established this plant also produced these effects of calcium metabolism via the same glycoside.[1]

In the 1990s, his laboratory made pioneering studies using ion microscopic imaging of calcium. He suggested "the presence of a vitamin D induced calcium channel in the intestine (later identified as the vitamin D regulated epithelial calcium channel, TRPV6)."[1]

Wasserman was a member of the editorial boards of the Proceedings of the Society for Experimental Biology and Medicine, The Cornell Veterinarian, Calcified Tissue International, and the Journal of Nutrition.[5] He was the author or co-author of more than 360 research articles, including 14 papers in Science and 7 papers in Nature. Wassermann was on sabbatical leave at the University of Copenhagen in 1964–1965, the University of Leeds in 1972, Woods Hole Marine Biological Laboratory in 1981, and the National Institute on Aging in 1982–1983. He participated in over 40 international conferences on calcium metabolism, bone health, calcification, and vitamin D.[1]

Robert Wasserman married Marilyn Joyce Mintz in 1950 in Ithaca.[1] He was predeceased by his wife after 63 years of marriage. Upon his death he was survived by three daughters and four grandchildren.[6]

Awards and honors

Selected publications

References
  1. Cousins, Robert J.; Christakos, Sylvia (2020). "Robert H. Wasserman 1926–2018" (PDF). Biographical Memoirs of the National Academy of Sciences.
  2. Roberts, Lauren Cahoon (July 9, 2018). "Robert H. Wasserman, discoverer of calcium-binding protein, dies at age 92". Cornell Chronicle. (This obituary erroneously states that Wasserman received his M.S. in 1951 — the correct year is 1950.)
  3. "The effect of certain antibiotics, crystal violet and sodium azide on the "in-vitro" cellulose digestion by ruminant microorganisms (Master's Thesis)". MSU Libraries, Michigan State University. 1950.
  4. "Remembering Professor Emeritus Robert Wasserman, discoverer of calcium-binding protein". Cornell University, College of Veterinary Medicine. June 28, 2018. (This obituary notice erroneously states that Wasserman received his M.S. in 1951 — the correct year is 1950.)
  5. "Biographical Sketches of Committee, Subcommittee, Panel Members and Staff". Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, Fluoride. Washington, D.C.: National Academies Press (U.S.). 1997.
  6. "Dr. Robert H. Wasserman 1926–2018". Ithaca Journal. June 14, 2018.
  7. "Robert Harold Wasserman". John Simon Guggenheim Memorial Foundation.
  8. "Robert H. Wasserman". National Academy of Sciences (nasonline.org).
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.