Ron Heeren

Ron M.A. Heeren (1965, Tilburg) is a Dutch scientist in mass spectrometry imaging. He is currently a distinguished professor at Maastricht University and the scientific director of the Multimodal Molecular Imaging Institute (M4I), where he heads the division of Imaging Mass Spectrometry.

Ron M.A. Heeren
Born1965
Tilburg, Netherlands
NationalityDutch
Alma materUniversity of Amsterdam
AwardsHans Fisher Fellowship; Thomson Medal of IMSF; NWO-Physics Valorisation Prize; Brightlands Convention Award; Robert Feulgen lecturer, Society for Histochemistry; Distinguished Wiley Visiting Scientist award;
Scientific career
FieldsImaging Mass Spectrometry

Scientific career

Heeren obtained a PhD degree in Technical Physics at the University of Amsterdam in 1992 under the supervision of Aart Kleyn.

He led a FOM-AMOLF research group on macromolecular ion physics and biomolecular imaging mass spectrometry (1995–2014). He was also professor at the chemistry faculty of Utrecht University in 2001–2019.

Between 1995 and 2015, he worked on new approaches towards high spatial resolution and high-throughput molecular imaging mass spectrometry using secondary ion mass spectrometry (SIMS) and matrix-assisted laser desorption and ionization (MALDI).

Heeren has coauthored over 300 peer-reviewed articles, which have been cited over 12,600 times (Google Scholar).[1]

Research

Heeren’s academic research interests are fundamental studies of the energetics of macromolecular systems, conformational studies of non-covalently bound protein complexes, translational imaging research, high-throughput bioinformatics, and the development and validation of new mass spectrometry–based proteomic imaging techniques for the life sciences.

During his postdoctoral fellowship, he worked on the development of innovative ion sources, vacuums systems, data acquisition systems and novel temperature-controlled ion cyclotron resonance cells. He used the FTICR-MS instrument for the study of collisional energy transfer and internal energy distributions.[2][3][4] These methods were deployed to investigate their role in the determination of dissociation pathways of biomolecular systems.[5][6]

As a project leader (1995–1997), Heeren led the application of high-resolution MS (FTICR-MS, FTIR imaging spectroscopy and SIMS) to the field of conservation science. He discovered and identified saponified pigment particulates in so-called protrusions in Rembrandt’s “The Anatomy Lesson of Dr. Nicolaes Tulp” in collaboration with the Mauritshuis museum in The Hague.[7][8][9]

Heeren and his group have pioneered the development of active pixelated detectors for mass spectrometry imaging. One such detector, the Medipix detector has been adapted to enable microscope-mode imaging mass spectrometry[10] for biomolecules to enable combined high-throughput and high-resolution molecular imaging using MALDI and SIMS.

Professional activities

From 2008 to 2013, Heeren was the research director for emerging technologies at the Netherlands Proteomics Centre. In 2014, he was appointed to his current position as one of the scientific directors of M4I at Maastricht University.[11]

Heeren is a member in the Dutch Physics Society (1993), The American Chemical Society (2010) and The American Society for Mass Spectrometry (1994). He was president of the Dutch Society of Mass Spectrometry between 2001–2005.[12] He is one of the founding members of the Mass Spectrometry Imaging Society, and was elected its president in 2017.[13]

Commercialization

Heeren holds 7 patents and has established two spin-off companies, Omics2Image/ASI and the Dutch Screening Group. In 2019, he was awarded the NWO Valorisation Prize in Physics.[14][15]

Awards
  • 2020     Hans Fisher Senior Fellowship, Institute of Advanced Studies, Technical University of Munich Hans Fisher senior fellowship[16]
  • 2020     Thomson medal, International Mass Spectrometry Foundation for distinguished contribution to international MS[17][18]
  • 2019     NWO-Physics Valorisation prize (see above)
  • 2019     Brightlands Convention Award[19]
  • 2014     Robert Feulgen lecturer, Society for Histochemistry[20]
  • 2013     Winner, 10th Venture Challenge, Netherlands Genomics Initiative[21]
  • 2012     Award, Exploratory Measurement Science Group (EMSG), University of Edinburgh, UK
  • 2010     Distinguished Wiley Visiting Scientist award, Environmental Molecular Sciences Laboratory, Department of Energy, US[22][23]
  • 2008     RCM Beynon Prize, Rapid Communications in Mass Spectrometry[24]
  • 2002     Bert L. Schram Award, Dutch Society for Mass Spectrometry (NVMS)

Most cited publications
  1. Ščupáková, Klára; Dewez, Frédéric; Walch, Axel K.; Heeren, Ron M. A.; Balluff, Benjamin (2020-08-17). "Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging". Angewandte Chemie International Edition. 59 (40): 17447–17450.[25]
  2. Ellis, Shane R.; Paine, Martin R. L.; Eijkel, Gert B.; Pauling, Josch K.; Husen, Peter; Jervelund, Mark W.; Hermansson, Martin; Ejsing, Christer S.; Heeren, Ron M. A. (2018-05-21). "Automated, parallel mass spectrometry imaging and structural identification of lipids". Nature Methods. 15 (7): 515–518.[26]
  3. Bruinen, Anne L.; Fisher, Gregory L.; Balez, Rachelle; van der Sar, Astrid M.; Ooi, Lezanne; Heeren, Ron M. A. (2018-06-12). "Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry". Journal of The American Society for Mass Spectrometry. 29 (8): 1571–1581.[27]
  4. Ščupáková, Klára; Soons, Zita; Ertaylan, Gökhan; Pierzchalski, Keely A.; Eijkel, Gert B.; Ellis, Shane R.; Greve, Jan W.; Driessen, Ann; Verheij, Joanne; De Kok, Theo M.; Olde Damink, Steven W. M. (04 17, 2018). "Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity". Analytical Chemistry. 90 (8): 5130–5138.[28]
  5. Ellis, S. R.; Soltwisch, J.; Paine, M. R. L.; Dreisewerd, K.; Heeren, R. M. A. (2017). "Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids". Chemical Communications. 53 (53): 7246–7249.[29]
  6. Ogrinc Potočnik, Nina; Porta, Tiffany; Becker, Michael; Heeren, Ron M. A.; Ellis, Shane R. (2015-10-28). "Use of advantageous, volatile matrices enabled by next-generation high-speed matrix-assisted laser desorption/ionization time-of-flight imaging employing a scanning laser beam". Rapid Communications in Mass Spectrometry. 29 (23): 2195–2203.[30]
  7. Ellis, Shane R.; Jungmann, Julia H.; Smith, Donald F.; Soltwisch, Jens; Heeren, Ron M. A. (2013-10-18). "Enhanced detection of high-mass proteins by using an active pixel detector". Angewandte Chemie (International Ed. in English). 52 (43): 11261–11264.[31]
  8. Jungmann, Julia H.; Smith, Donald F.; MacAleese, Luke; Klinkert, Ivo; Visser, Jan; Heeren, Ron M. A. (2012-07-27). "Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector". Journal of The American Society for Mass Spectrometry. 23 (10): 1679–1688.[32]
  9. Jungmann, Julia H.; MacAleese, Luke; Visser, Jan; Vrakking, Marc J. J.; Heeren, Ron M. A. (2011-10-15). "High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector". Analytical Chemistry. 83 (20): 7888–7894.[33]
  10. Chughtai, Kamila; Heeren, Ron M. A. (2010-05-12). "Mass Spectrometric Imaging for Biomedical Tissue Analysis". Chemical Reviews. 110 (5): 3237–3277.[34]

References
  1. "Ron M.A. Heeren". scholar.google.nl. Retrieved 2020-12-18.
  2. Heeren, Ron M. A.; Vékey, Károly (1998-09-15). <1175::aid-rcm305>3.0.co;2-l "A novel method to determine collisional energy transfer efficiency by Fourier transform ion cyclotron resonance mass spectrometry". Rapid Communications in Mass Spectrometry. 12 (17): 1175–1181. doi:10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l. ISSN 0951-4198.
  3. Drahos, null; Heeren, null; Collette, null; De Pauw E, null; Vekey, null (December 1999). "Thermal energy distribution observed in electrospray ionization". Journal of Mass Spectrometry: JMS. 34 (12): 1373–1379. Bibcode:1999JMSp...34.1373D. doi:10.1002/(SICI)1096-9888(199912)34:12<1373::AID-JMS907>3.0.CO;2-#. ISSN 1096-9888. PMID 10587635.
  4. Guo, Xinghua; Duursma, Marc C.; Kistemaker, Piet G.; Nibbering, Nico M. M.; Vekey, Karoly; Drahos, Laszlo; Heeren, Ron M. A. (June 2003). "Manipulating internal energy of protonated biomolecules in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry". Journal of Mass Spectrometry: JMS. 38 (6): 597–606. Bibcode:2003JMSp...38..597G. doi:10.1002/jms.480. ISSN 1076-5174. PMID 12827629.
  5. Koster, Sander; Duursma, Marc C.; Boon, Jaap J.; Nielen, Michel W. F.; de Koster, Chris G.; Heeren, Ron M. A. (2000). <739::aid-jms3>3.0.co;2-# "Structural analysis of synthetic homo- and copolyesters by electrospray ionization on a Fourier transform ion cyclotron resonance mass spectrometer". Journal of Mass Spectrometry. 35 (6): 739–748. Bibcode:2000JMSp...35..739K. doi:10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#. ISSN 1076-5174. PMID 10862127.
  6. Kleinnijenhuis, Anne J.; Duursma, Marc C.; Breukink, Eefjan; Heeren, Ron M. A.; Heck, Albert J. R. (2003-07-01). "Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation". Analytical Chemistry. 75 (13): 3219–3225. doi:10.1021/ac0263770. hdl:1874/14955. ISSN 0003-2700. PMID 12964772.
  7. Heeren, Ron M. A.; Boon, Jaap J.; Noble, Petria; Wadum, Jørgen (1999). "Integrating imaging FTIR and secondary ion mass spectrometry for the analysis of embedded paint cross-sections". ICOM-CC Triennial Meeting (12th), Lyon, 29 August-3 September 1999: Preprints.: 228–233.
  8. "Recitative after Rembrandt's "The Anatomy Lesson of Dr. Nicolaes Tulp"", 90 Miles, University of Pittsburgh Press, pp. 78–79, 2005-03-23, doi:10.2307/j.ctvthhc5r.38, ISBN 978-0-8229-8033-9, retrieved 2020-12-18
  9. Van Der Weerd, J.; Brammer, H.; Boon, J. J.; Heeren, R. M. A. (March 2002). "Fourier Transform Infrared Microscopic Imaging of an Embedded Paint Cross-Section". Applied Spectroscopy. 56 (3): 275–283. Bibcode:2002ApSpe..56Q.275V. doi:10.1366/0003702021954683. ISSN 0003-7028. S2CID 95454503.
  10. Jungmann, Julia H.; MacAleese, Luke; Visser, Jan; Vrakking, Marc J. J.; Heeren, Ron M. A. (2011-10-15). "High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector". Analytical Chemistry. 83 (20): 7888–7894. doi:10.1021/ac2017629. ISSN 0003-2700. PMID 21882854.
  11. "Maastricht University Magazine October 2014". Issuu. Retrieved 2020-12-18.
  12. "History". NVMS. Retrieved 2020-12-18.
  13. "Mass Spectrometry Imaging Society – MS Imaging". ms-imaging.org. Retrieved 2020-12-18.
  14. "NWO Physics Valorisation Prize 2019 - Ron Heeren - YouTube". www.youtube.com. Retrieved 2020-12-18.
  15. "NWO Physics Valorisation Prize goes to Ron Heeren from Maastricht University | NWO". www.nwo.nl. Retrieved 2020-12-18.
  16. "Heeren, Ron M.A. - Institute for Advanced Study (IAS)". www.ias.tum.de (in German). Retrieved 2020-12-18.
  17. Maastricht, Minderbroedersberg 4-6 6211 LK. "Thomson Medal 2020 awarded to Ron Heeren". www.maastrichtuniversity.nl. Retrieved 2020-12-18.
  18. "International Mass Spectronomy Foundation". www.imss.nl. Retrieved 2020-12-18.
  19. Redactie (2019-03-27). "Uitreiking Brightlands Convention Award 2018". Conference Matters (in Dutch). Retrieved 2020-12-18.
  20. "Society for Histochemistry". www.histochemistry.eu. Retrieved 2020-12-18.
  21. "Press release: Omics2Image wins Venture Challenge Spring 2013" (PDF).
  22. "iDirector interview with Ron Heeren - YouTube". www.youtube.com. Retrieved 2020-12-18.
  23. "New EMSL Visiting Scientists Named".
  24. "Rapid Communications in Mass Spectrometry". Wiley Online Library. Retrieved 2020-12-18.
  25. Ščupáková, Klára; Dewez, Frédéric; Walch, Axel K.; Heeren, Ron M. A.; Balluff, Benjamin (2020-08-17). "Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging". Angewandte Chemie International Edition. 59 (40): 17447–17450. doi:10.1002/anie.202007315. ISSN 1433-7851. PMC 7540554. PMID 32668069.
  26. Ellis, Shane R.; Paine, Martin R. L.; Eijkel, Gert B.; Pauling, Josch K.; Husen, Peter; Jervelund, Mark W.; Hermansson, Martin; Ejsing, Christer S.; Heeren, Ron M. A. (2018-05-21). "Automated, parallel mass spectrometry imaging and structural identification of lipids". Nature Methods. 15 (7): 515–518. doi:10.1038/s41592-018-0010-6. ISSN 1548-7091. PMID 29786091. S2CID 29162438.
  27. Bruinen, Anne L.; Fisher, Gregory L.; Balez, Rachelle; van der Sar, Astrid M.; Ooi, Lezanne; Heeren, Ron M. A. (2018-06-12). "Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry". Journal of the American Society for Mass Spectrometry. 29 (8): 1571–1581. Bibcode:2018JASMS..29.1571B. doi:10.1007/s13361-018-1979-x. ISSN 1044-0305. PMC 6060986. PMID 29949055.
  28. Ščupáková, Klára; Soons, Zita; Ertaylan, Gökhan; Pierzchalski, Keely A.; Eijkel, Gert B.; Ellis, Shane R.; Greve, Jan W.; Driessen, Ann; Verheij, Joanne; De Kok, Theo M.; Olde Damink, Steven W. M. (04 17, 2018). "Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity". Analytical Chemistry. 90 (8): 5130–5138. doi:10.1021/acs.analchem.7b05215. ISSN 1520-6882. PMC 5906754. PMID 29570976. Check date values in: |date= (help)
  29. Ellis, S. R.; Soltwisch, J.; Paine, M. R. L.; Dreisewerd, K.; Heeren, R. M. A. (2017). "Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids". Chemical Communications. 53 (53): 7246–7249. doi:10.1039/c7cc02325a. ISSN 1359-7345. PMID 28573274.
  30. Ogrinc Potočnik, Nina; Porta, Tiffany; Becker, Michael; Heeren, Ron M. A.; Ellis, Shane R. (2015-10-28). "Use of advantageous, volatile matrices enabled by next-generation high-speed matrix-assisted laser desorption/ionization time-of-flight imaging employing a scanning laser beam". Rapid Communications in Mass Spectrometry. 29 (23): 2195–2203. Bibcode:2015RCMS...29.2195O. doi:10.1002/rcm.7379. ISSN 0951-4198. PMID 26522310.
  31. Ellis, Shane R.; Jungmann, Julia H.; Smith, Donald F.; Soltwisch, Jens; Heeren, Ron M. A. (2013-10-18). "Enhanced detection of high-mass proteins by using an active pixel detector". Angewandte Chemie (International ed. In English). 52 (43): 11261–11264. doi:10.1002/anie.201305501. ISSN 1521-3773. PMID 24039122.
  32. Jungmann, Julia H.; Smith, Donald F.; MacAleese, Luke; Klinkert, Ivo; Visser, Jan; Heeren, Ron M. A. (2012-07-27). "Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector". Journal of the American Society for Mass Spectrometry. 23 (10): 1679–1688. arXiv:1305.5437. Bibcode:2012JASMS..23.1679J. doi:10.1007/s13361-012-0444-5. ISSN 1044-0305. PMID 22836864. S2CID 13480751.
  33. Jungmann, Julia H.; MacAleese, Luke; Visser, Jan; Vrakking, Marc J. J.; Heeren, Ron M. A. (2011-10-15). "High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector". Analytical Chemistry. 83 (20): 7888–7894. doi:10.1021/ac2017629. ISSN 0003-2700. PMID 21882854.
  34. Chughtai, Kamila; Heeren, Ron M. A. (2010-05-12). "Mass Spectrometric Imaging for Biomedical Tissue Analysis". Chemical Reviews. 110 (5): 3237–3277. doi:10.1021/cr100012c. ISSN 0009-2665. PMC 2907483. PMID 20423155.


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