S100A5

S100 calcium-binding protein A5 (S100A5) is a protein that in humans is encoded by the S100A5 gene.[5][6]

S100A5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS100A5, S100D, S100 calcium binding protein A5
External IDsOMIM: 176991 MGI: 1338915 HomoloGene: 2224 GeneCards: S100A5
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.3Start153,537,147 bp[1]
End153,541,765 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6276

20199

Ensembl

ENSG00000196420

ENSMUSG00000001023

UniProt

P33763

P63084

RefSeq (mRNA)

NM_002962

NM_011312

RefSeq (protein)

NP_002953

NP_035442

Location (UCSC)Chr 1: 153.54 – 153.54 MbChr 3: 90.61 – 90.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000196420 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001023 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. Bibcode:1993PNAS...90.6547E. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
  6. "Entrez Gene: S100A5 S100 calcium binding protein A5".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.