S100A8

S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene.[5] It is also known as calgranulin A.

S100A8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MR8, 1XK4, 4GGF, 4XJK, 5HLO, 5HLV
Identifiers
Aliases	S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium binding protein A8
External IDs	OMIM: 123885 MGI: 88244 HomoloGene: 2225 GeneCards: S100A8
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,390,032 bp[1] End 153,391,073 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.9 cM Start 90,668,978 bp[2] End 90,670,035 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Toll-like receptor 4 binding • RAGE receptor binding • microtubule binding • GO:0001948 protein binding • calcium ion binding • arachidonic acid binding • zinc ion binding • metal ion binding Cellular component • cell nucleus • cytoskeleton • cytosol • extracellular exosome • membrane • cell membrane • cytoplasm • extracellular • secretory granule lumen • intermediate filament cytoskeleton • extracellular region • collagen-containing extracellular matrix Biological process • regulation of inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • immune system process • positive regulation of inflammatory response • neutrophil chemotaxis • positive regulation of intrinsic apoptotic signaling pathway • defense response to fungus • response to ethanol • chemokine production • response to zinc ion • acute inflammatory response • defense response to bacterium • leukocyte migration involved in inflammatory response • peptidyl-cysteine S-nitrosylation • sequestering of zinc ion • neutrophil aggregation • response to lipopolysaccharide • chemotaxis • positive regulation of peptide secretion • chronic inflammation • astrocyte development • wound healing • apoptotic process • positive regulation of cell growth • autophagy • inflammatory response • regulation of cytoskeleton organization • cytokine production • positive regulation of NF-kappaB transcription factor activity • innate immune system • toll-like receptor signaling pathway • antimicrobial humoral response • neutrophil degranulation • autocrine signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6279	20201
Ensembl	ENSG00000143546	ENSMUSG00000056054
UniProt	P05109	P27005
RefSeq (mRNA)	NM_002964 NM_001319196 NM_001319197 NM_001319198 NM_001319201	NM_013650
RefSeq (protein)	NP_001306125 NP_001306126 NP_001306127 NP_001306130 NP_002955	NP_038678
Location (UCSC)	Chr 1: 153.39 – 153.39 Mb	Chr 3: 90.67 – 90.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.[5]