SCO-spondin

SCO-spondin is a protein that in humans is encoded by the SSPO gene.[4][5][6] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.[7]

SSPOP
Identifiers
AliasesSSPOP, SCO-spondin, SCO-spondin, pseudogene, SSPO
External IDsOMIM: 617356 MGI: 2674311 HomoloGene: 45453 GeneCards: SSPOP
Orthologs
SpeciesHumanMouse
Entrez

23145

243369

Ensembl

n/a

ENSMUSG00000029797

UniProt

A2VEC9

Q8CG65

RefSeq (mRNA)

n/a

NM_173428

RefSeq (protein)

NP_940857

NP_775604

Location (UCSC)n/aChr 6: 48.45 – 48.5 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000029797 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (May 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". Journal of Cell Science. 109. 109 ( Pt 5): 1053–61. PMID 8743952.
  5. Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (November 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia. 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217.
  6. "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)".
  7. Gobron S, Creveaux I, Meiniel R, Didier R, Dastugue B, Meiniel A (January 1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience. 88 (2): 655–64. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783. S2CID 426154.

Further reading

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