SEC61B

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.[5][6][7]

SEC61B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEC61B, Sec61 translocon beta subunit, SEC61 translocon subunit beta
External IDsOMIM: 609214 MGI: 1913462 HomoloGene: 38229 GeneCards: SEC61B
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q22.33Start99,222,064 bp[1]
End99,230,615 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10952

66212

Ensembl

ENSG00000106803

ENSMUSG00000053317

UniProt

P60468

Q9CQS8

RefSeq (mRNA)

NM_006808

NM_024171

RefSeq (protein)

NP_006799

NP_077133

Location (UCSC)Chr 9: 99.22 – 99.23 MbChr 4: 47.47 – 47.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000106803 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053317 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.
  6. Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci. 112 (10): 1477–86. PMID 10212142.
  7. "Entrez Gene: SEC61B Sec61 beta subunit".

Further reading

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