SEMA4C

SEMA4C
Identifiers
Aliases	SEMA4C, M-SEMA-F, SEMACL1, SEMAF, SEMAI, semaphorin 4C
External IDs	OMIM: 604462 MGI: 109252 HomoloGene: 23047 GeneCards: SEMA4C
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	96,870,757 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	36,558,349 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • neuropilin binding; • semaphorin receptor binding; • chemorepellent activity;
Cellular component	• integral component of membrane; • postsynaptic membrane; • GO:0097483, GO:0097481 postsynaptic density; • cell membrane; • synapse; • synaptic vesicle membrane; • cell junction; • cytoplasmic vesicle; • extracellular; • membrane; • integral component of plasma membrane;
Biological process	• cell differentiation; • cell migration in hindbrain; • cerebellum development; • nervous system development; • multicellular organism development; • muscle cell differentiation; • neural tube closure; • positive regulation of stress-activated MAPK cascade; • semaphorin-plexin signaling pathway; • negative chemotaxis; • neural crest cell migration; • positive regulation of cell migration; • negative regulation of axon extension involved in axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	54910
	20353
	ENSG00000168758
	ENSMUSG00000026121
	Q9C0C4
	Q64151
	NM_017789
	NM_001126047; NM_001304329; NM_001304330
	NP_060259
	NP_001119519; NP_001291258; NP_001291259
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-4C is a protein that in humans is encoded by the SEMA4C gene.[5][6]

Interactions

SEMA4C has been shown to interact with DLG4.[7]

References

GRCh38: Ensembl release 89: ENSG00000168758 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026121 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Inagaki S, Furuyama T, Iwahashi Y (October 1995). "Identification of a member of mouse semaphorin family". FEBS Lett. 370 (3): 269–72. doi:10.1016/0014-5793(95)00850-9. PMID 7656991.
"Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C".
Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (March 2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.

Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M (1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem. Biophys. Res. Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF". J. Biol. Chem. 274 (20): 14137–46. doi:10.1074/jbc.274.20.14137. PMID 10318831.
Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.
Ohoka Y, Hirotani M, Sugimoto H, Fujioka S, Furuyama T, Inagaki S (2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75". Biochem. Biophys. Res. Commun. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168758 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026121 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7656991-5] Inagaki S, Furuyama T, Iwahashi Y (October 1995). "Identification of a member of mouse semaphorin family". FEBS Lett. 370 (3): 269–72. doi:10.1016/0014-5793(95)00850-9. PMID 7656991.

[entrez-6] "Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C".

[pmid11134026-7] Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (March 2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.

SEMA4C

Interactions

References

Further reading