SEPP1

Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.[5][6]

SELENOP
Identifiers
AliasesSELENOP, SELP, SeP, SEPP, SEPP1, selenoprotein P, plasma, 1, selenoprotein P
External IDsOMIM: 601484 MGI: 894288 HomoloGene: 3945 GeneCards: SELENOP
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p12Start42,799,880 bp[1]
End42,887,392 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

6414

20363

Ensembl

ENSG00000250722

ENSMUSG00000064373

UniProt

P49908

P70274

RefSeq (mRNA)

NM_005410
NM_001085486
NM_001093726

NM_001042613
NM_001042614
NM_009155

RefSeq (protein)

NP_001078955
NP_001087195
NP_005401

NP_001036078
NP_001036079
NP_033181

Location (UCSC)Chr 5: 42.8 – 42.89 MbChr 15: 3.27 – 3.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues (human, rat, mouse - see Burk and Hill 2009) per polypeptide, one of which located at the C-termial side of protein and others at the N-terminal side. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000250722 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000064373 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hill KE, Lloyd RS, Burk RF (Feb 1993). "Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA". Proc Natl Acad Sci U S A. 90 (2): 537–41. doi:10.1073/pnas.90.2.537. PMC 45698. PMID 8421687.
  6. "Entrez Gene: SEPP1 selenoprotein P, plasma, 1".

Further reading

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