SEPX1

MSRB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MAO
Identifiers
Aliases	MSRB1, SELR, SELX, SEPX1, SepR, HSPC270, methionine sulfoxide reductase B1
External IDs	OMIM: 606216 MGI: 1351642 HomoloGene: 8455 GeneCards: MSRB1
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	1,943,326 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	24,742,778 bp[2]
Gene ontology
Molecular function	• oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; • oxidoreductase activity; • actin binding; • zinc ion binding; • metal ion binding; • methionine-R-sulfoxide reductase activity; • peptide-methionine (R)-S-oxide reductase activity; • L-methionine-(R)-S-oxide reductase activity; • GO:0001948 protein binding;
Cellular component	• cytoplasm; • cytosol; • cytoskeleton; • cell nucleus; • actin cytoskeleton; • cellular component;
Biological process	• immune system process; • actin filament polymerization; • innate immune system; • oxidation-reduction process; • response to oxidative stress; • protein repair;
	Sources:Amigo / QuickGO
Orthologs
	51734
	27361
	ENSG00000198736
	ENSMUSG00000075705
	Q9NZV6
	Q9JLC3
	NM_016332; NM_001382264; NM_001382265
	NM_013759; NM_001346668
	NP_057416; NP_001369193; NP_001369194
	NP_001333597; NP_038787
	Wikidata
View/Edit Human	View/Edit Mouse

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.[5][6]

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.[6]

References

GRCh38: Ensembl release 89: ENSG00000198736 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000075705 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lescure A, Gautheret D, Carbon P, Krol A (Feb 2000). "Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif". J Biol Chem. 274 (53): 38147–54. doi:10.1074/jbc.274.53.38147. PMID 10608886.
"Entrez Gene: SEPX1 selenoprotein X, 1".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Kryukov GV, Kryukov VM, Gladyshev VN (1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Moskovitz J, Singh VK, Requena J, et al. (2002). "Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity". Biochem. Biophys. Res. Commun. 290 (1): 62–5. doi:10.1006/bbrc.2001.6171. PMID 11779133.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim HY, Gladyshev VN (2004). "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases". Mol. Biol. Cell. 15 (3): 1055–64. doi:10.1091/mbc.E03-08-0629. PMC 363075. PMID 14699060.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198736 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000075705 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10608886-5] Lescure A, Gautheret D, Carbon P, Krol A (Feb 2000). "Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif". J Biol Chem. 274 (53): 38147–54. doi:10.1074/jbc.274.53.38147. PMID 10608886.

[entrez-6] "Entrez Gene: SEPX1 selenoprotein X, 1".

SEPX1

See also

References

Further reading