SESN1

SESN1
Identifiers
Aliases	SESN1, PA26, SEST1, sestrin 1
External IDs	OMIM: 606103 MGI: 2155278 HomoloGene: 8697 GeneCards: SESN1
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	109,094,819 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	41,908,424 bp[2]
Gene ontology
Molecular function	• oxidoreductase activity; • peroxiredoxin activity; • GO:0001948 protein binding; • leucine binding; • oxidoreductase activity, acting on peroxide as acceptor;
Cellular component	• cytosol; • cytoplasm; • GATOR2 complex; • cell nucleus; • fibrillar center; • TORC2 complex;
Biological process	• regulation of response to reactive oxygen species; • oxidation-reduction process; • reactive oxygen species metabolic process; • cellular oxidant detoxification; • negative regulation of TORC1 signaling; • cellular response to amino acid starvation; • cellular response to glucose starvation; • positive regulation of macroautophagy; • cellular response to amino acid stimulus; • cellular response to leucine; • cellular response to leucine starvation;
	Sources:Amigo / QuickGO
Orthologs
	27244
	140742
	ENSG00000080546
	ENSMUSG00000038332
	Q9Y6P5
	P58006
	NM_014454; NM_001199933; NM_001199934
	NM_001013370; NM_001162908
	NP_001186862; NP_001186863; NP_055269
	NP_001013388; NP_001156380
	Wikidata
View/Edit Human	View/Edit Mouse

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000080546 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038332 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: sestrin 1".
Buckbinder L, Talbott R, Seizinger BR, Kley N (October 1994). "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (22): 10640–4. Bibcode:1994PNAS...9110640B. doi:10.1073/pnas.91.22.10640. PMC 45077. PMID 7938006.
Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene. 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID 9926927.

Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM (April 2004). "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD". Science. 304 (5670): 596–600. Bibcode:2004Sci...304..596B. doi:10.1126/science.1095569. PMID 15105503. S2CID 27871118.
Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K (May 2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Human Genetics. 112 (5–6): 573–80. doi:10.1007/s00439-003-0917-5. PMID 12607115. S2CID 22257894.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080546 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038332 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: sestrin 1".

[pmid7938006-6] Buckbinder L, Talbott R, Seizinger BR, Kley N (October 1994). "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (22): 10640–4. Bibcode:1994PNAS...9110640B. doi:10.1073/pnas.91.22.10640. PMC 45077. PMID 7938006.

[pmid9926927-7] Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene. 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID 9926927.

SESN1

See also

References

Further reading