SF3B2

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.[5][6]

SF3B2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSF3B2, Cus1, SAP145, SF3B145, SF3b1, SF3b150, splicing factor 3b subunit 2
External IDsOMIM: 605591 MGI: 2441856 HomoloGene: 6678 GeneCards: SF3B2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start66,050,729 bp[1]
End66,069,308 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10992

319322

Ensembl

ENSG00000087365

ENSMUSG00000024853

UniProt

Q13435

Q3UJB0

RefSeq (mRNA)

NM_006842

NM_030109
NM_001362454

RefSeq (protein)

NP_006833

NP_084385
NP_001349383

Location (UCSC)Chr 11: 66.05 – 66.07 MbChr 19: 5.27 – 5.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.[6]

Interactions

SF3B2 has been shown to interact with SF3B4,[7][8] RBM7,[9] SF3B1[10][11] and CDC5L.[12]

References

  1. GRCh38: Ensembl release 89: ENSG00000087365 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024853 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gozani O, Feld R, Reed R (Jan 1996). "Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A". Genes & Development. 10 (2): 233–43. doi:10.1101/gad.10.2.233. PMID 8566756.
  6. "Entrez Gene: SF3B2 splicing factor 3b, subunit 2, 145kDa".
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  8. Champion-Arnaud P, Reed R (Aug 1994). "The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site". Genes & Development. 8 (16): 1974–83. doi:10.1101/gad.8.16.1974. PMID 7958871.
  9. Guo TB, Boros LG, Chan KC, Hikim AP, Hudson AP, Swerdloff RS, Mitchell AP, Salameh WA (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". Journal of Andrology. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.
  10. Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R (Oct 1999). "Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155". Molecular and Cellular Biology. 19 (10): 6796–802. doi:10.1128/mcb.19.10.6796. PMC 84676. PMID 10490618.
  11. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.
  12. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

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