SH2B2

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.[5][6]

SH2B2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSH2B2, APS, SH2B adaptor protein 2
External IDsOMIM: 605300 MGI: 1345171 HomoloGene: 10309 GeneCards: SH2B2
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.1Start102,285,091 bp[1]
End102,321,711 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10603

23921

Ensembl

ENSG00000160999

ENSMUSG00000005057

UniProt

O14492

Q9JID9

RefSeq (mRNA)

NM_020979
NM_001359228
NM_001359229
NM_001359230
NM_001359231

NM_018825
NM_001302938
NM_001302939

RefSeq (protein)

NP_066189
NP_001346157
NP_001346158
NP_001346159
NP_001346160

NP_001289867
NP_001289868
NP_061295

Location (UCSC)Chr 7: 102.29 – 102.32 MbChr 5: 136.22 – 136.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.[6]

Interactions

SH2B2 has been shown to interact with TrkA[7] and Cbl gene.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000160999 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000005057 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A (Aug 1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene. 15 (1): 7–15. doi:10.1038/sj.onc.1201163. PMID 9233773.
  6. "Entrez Gene: SH2B2 SH2B adaptor protein 2".
  7. Qian X, Riccio A, Zhang Y, Ginty DD (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi:10.1016/S0896-6273(00)80620-0. PMID 9856458. S2CID 12354383.
  8. Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi:10.1038/sj/leu/2401397. PMID 10374881.
  9. Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755. PMID 18273061.

Further reading


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