SH2D1B

SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1B gene.[5][6][7]

SH2D1B
Identifiers
AliasesSH2D1B, EAT2, SH2 domain containing 1B
External IDsOMIM: 608510 MGI: 1349420 HomoloGene: 8070 GeneCards: SH2D1B
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start162,395,268 bp[1]
End162,412,138 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

117157

26904

Ensembl

ENSG00000198574

ENSMUSG00000102418

UniProt

O14796

O35324
Q149T1

RefSeq (mRNA)

NM_053282

NM_012009

RefSeq (protein)

NP_444512

NP_036139

Location (UCSC)Chr 1: 162.4 – 162.41 MbChr 1: 170.28 – 170.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM][7]

Interactions

SH2D1B has been shown to interact with SLAMF1.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000198574 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000102418 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Thompson AD, Braun BS, Arvand A, Stewart SD, May WA, Chen E, Korenberg J, Denny C (Feb 1997). "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene". Oncogene. 13 (12): 2649–58. PMID 9000139.
  6. Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (Nov 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
  7. "Entrez Gene: SH2D1B SH2 domain containing 1B".

Further reading


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