SHOC2

SHOC2
Identifiers
Aliases	SHOC2, SIAA0862, SOC2, SUR8, SHOC2 leucine-rich repeat scaffold protein, leucine rich repeat scaffold protein, SHOC2 leucine rich repeat scaffold protein
External IDs	OMIM: 602775 MGI: 1927197 HomoloGene: 7219 GeneCards: SHOC2
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	111,013,667 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	54,033,133 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein phosphatase 1 binding; • protein phosphatase regulator activity; • protein phosphatase binding; • GO:0001948 protein binding; • protein serine/threonine phosphatase activity;
Cellular component	• protein phosphatase type 1 complex; • nucleoplasm; • cell nucleus; • cytoplasm; • cytosol; • cell membrane; • photoreceptor inner segment; • photoreceptor outer segment membrane;
Biological process	• fibroblast growth factor receptor signaling pathway; • positive regulation of Ras protein signal transduction; • Ras protein signal transduction; • regulation of phosphoprotein phosphatase activity; • protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	8036
	56392
	ENSG00000108061
	ENSMUSG00000024976
	Q9UQ13
	O88520
	NM_001269039; NM_007373; NM_001324336; NM_001324337
	NM_001168505; NM_019658; NM_001355242
	NP_001255968; NP_001311265; NP_001311266; NP_031399
	NP_001161977; NP_062632; NP_001342171
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene.[5][6][7][8] Mutations that result in lipidation (specifically Myristoylation) of SHOC2 can cause Noonan syndrome.[9]

Interactions

SHOC2 has been shown to interact with C-Raf[7] and HRAS.[7]

References

GRCh38: Ensembl release 89: ENSG00000108061 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024976 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Selfors LM, Schutzman JL, Borland CZ, Stern MJ (Jul 1998). "soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6903–8. doi:10.1073/pnas.95.12.6903. PMC 22679. PMID 9618511.
Sieburth DS, Sun Q, Han M (Aug 1998). "SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans". Cell. 94 (1): 119–30. doi:10.1016/S0092-8674(00)81227-1. PMID 9674433. S2CID 13102676.
Li W, Han M, Guan KL (May 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8): 895–900. PMC 316541. PMID 10783161.
"Entrez Gene: SHOC2 soc-2 suppressor of clear homolog (C. elegans)".
Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, Flex E, Lepri F, Bartholdi D, Kutsche K, Ferrero GB, Anichini C, Selicorni A, Rossi C, Tenconi R, Zenker M, Merlo D, Dallapiccola B, Iyengar R, Bazzicalupo P, Gelb BD, Tartaglia M (Sep 2009). "Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair". Nature Genetics. 41 (9): 1022–6. doi:10.1038/ng.425. PMC 2765465. PMID 19684605.

SHOC2

Interactions

References

Further reading