SIPA1

SIPA1
Identifiers
Aliases	SIPA1, SPA1, signal-induced proliferation-associated 1
External IDs	OMIM: 602180 MGI: 107576 HomoloGene: 7940 GeneCards: SIPA1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	65,650,918 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	5,663,707 bp[2]
Gene ontology
Molecular function	• GO:0001948 protein binding; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • protein C-terminus binding;
Cellular component	• cytoplasm; • perinuclear region of cytoplasm; • cytosol; • transport vesicle; • membrane; • endomembrane system; • cell nucleus; • macromolecular complex;
Biological process	• negative regulation of cell adhesion; • negative regulation of cell cycle; • cellular response to water deprivation; • cellular proliferation; • GO:0007243 intracellular signal transduction; • regulation of small GTPase mediated signal transduction; • cytoskeleton organization; • negative regulation of cell growth; • signal transduction; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	6494
	20469
	ENSG00000213445
	ENSMUSG00000056917
	Q96FS4
	P46062
	NM_006747; NM_153253
	NM_001164480; NM_001164481; NM_001164482; NM_001164568; NM_011379
	NP_006738; NP_694985
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.[5][6]

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.[6]

References

GRCh38: Ensembl release 89: ENSG00000213445 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000056917 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wada Y, Kubota H, Maeda M, Taniwaki M, Hattori M, Imamura S, Iwai K, Minato N (Mar 1997). "Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human". Genomics. 39 (1): 66–73. doi:10.1006/geno.1996.4464. PMID 9027487.
"Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1".

Minato N (1997). "[Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene]". Hum. Cell. 9 (1): 11–6. PMID 9183624.
Hattori M, Tsukamoto N, Nur-e-Kamal MS, et al. (1995). "Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression". Mol. Cell. Biol. 15 (1): 552–60. doi:10.1128/mcb.15.1.552. PMC 232010. PMID 7799964.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Kurachi H, Wada Y, Tsukamoto N, et al. (1997). "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product". J. Biol. Chem. 272 (44): 28081–8. doi:10.1074/jbc.272.44.28081. PMID 9346962. S2CID 26338837.
Ebrahimi S, Wang E, Udar N, et al. (1998). "Genomic organization and cloning of the human homologue of murine Sipa-1". Gene. 214 (1–2): 215–21. doi:10.1016/S0378-1119(98)00212-1. PMID 9651531.
Tsukamoto N, Hattori M, Yang H, et al. (1999). "Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion". J. Biol. Chem. 274 (26): 18463–9. doi:10.1074/jbc.274.26.18463. PMID 10373454. S2CID 46045210.
Hoecker U, Quail PH (2001). "The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis". J. Biol. Chem. 276 (41): 38173–8. doi:10.1074/jbc.M103140200. PMID 11461903.
Roy BC, Kohu K, Matsuura K, et al. (2003). "SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus". Genes Cells. 7 (6): 607–17. doi:10.1046/j.1365-2443.2002.00546.x. PMID 12059963. S2CID 42090467.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Farina A, Hattori M, Qin J, et al. (2004). "Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization". Mol. Cell. Biol. 24 (20): 9059–69. doi:10.1128/MCB.24.20.9059-9069.2004. PMC 517877. PMID 15456879.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Crawford NP, Ziogas A, Peel DJ, et al. (2006). "Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer". Breast Cancer Res. 8 (2): R16. doi:10.1186/bcr1389. PMC 1483843. PMID 16563182.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213445 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056917 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9027487-5] Wada Y, Kubota H, Maeda M, Taniwaki M, Hattori M, Imamura S, Iwai K, Minato N (Mar 1997). "Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human". Genomics. 39 (1): 66–73. doi:10.1006/geno.1996.4464. PMID 9027487.

[entrez-6] "Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1".

SIPA1

References

Further reading