SIVA1

Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.[4][5] This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.[5]

SIVA1
Identifiers
AliasesSIVA1, CD27BP, SIVA, Siva-1, Siva-2, SIVA1 apoptosis inducing factor
External IDsOMIM: 605567 MGI: 1353606 HomoloGene: 4692 GeneCards: SIVA1
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q32.33Start104,753,147 bp[1]
End104,768,494 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10572

30954

Ensembl

ENSG00000184990

ENSMUSG00000064326

UniProt

O15304

O54926

RefSeq (mRNA)

NM_006427
NM_021709

NM_001161737
NM_013929

RefSeq (protein)

NP_006418
NP_068355

NP_001155209
NP_038957

Location (UCSC)Chr 14: 104.75 – 104.77 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

SIVA1 has been shown to interact with CD27.[4]

Siva (protein)

Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor-suppressors p53 and E2F1. [6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000184990 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jul 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc Natl Acad Sci U S A. 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. PMC 21052. PMID 9177220.
  5. "Entrez Gene: SIVA1 SIVA1, apoptosis-inducing factor".
  6. Fortin A, MacLaurin JG, Arbour N, et al. (July 2004). "The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1". J. Biol. Chem. 279 (27): 28706–14. doi:10.1074/jbc.M400376200. PMID 15105421.

Further reading

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