SLC22A8

Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene.[5][6][7]

SLC22A8
Identifiers
AliasesSLC22A8, OAT3, solute carrier family 22 member 8
External IDsOMIM: 607581 MGI: 1336187 HomoloGene: 20901 GeneCards: SLC22A8
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q12.3Start62,989,154 bp[1]
End63,015,841 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9376

19879

Ensembl

ENSG00000149452

ENSMUSG00000063796

UniProt

Q8TCC7

O88909

RefSeq (mRNA)

NM_001184732
NM_001184733
NM_001184736
NM_004254

NM_001164634
NM_001164635
NM_031194

RefSeq (protein)

NP_001171661
NP_001171662
NP_001171665
NP_004245

NP_001158106
NP_001158107
NP_112471

Location (UCSC)Chr 11: 62.99 – 63.02 MbChr 19: 8.59 – 8.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

OAT3 is involved in the transport and excretion of organic ions some of which are drugs (e.g., penicillin G (benzylpenicillin), methotrexate (MTX), indomethacin (an NSAID), and ciprofloxacin (a fluoroquinolone antibiotic)) and some of which are pure toxicants.[6] SLC22A8 (OAT3) is indirectly dependent on the inward sodium gradient, which is a driving force for reentry of dicarboxylates into the cytosol. Dicarboxylates, such as alpha-ketoglutarate generated within the cell, or recycled from the extracellular space, are used as exchange substrates to fuel the influx of organic anions against their concentration gradient. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of renal proximal tubule cells.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000149452 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000063796 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). "Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)". Biochemical and Biophysical Research Communications. 255 (2): 508–14. doi:10.1006/bbrc.1998.9978. PMID 10049739.
  6. VanWert AL, Gionfriddo MR, Sweet DH (2009). "Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology". Biopharmaceutics & Drug Disposition. 31 (1): 1–71. doi:10.1002/bdd.693. PMID 19953504.
  7. EntrezGene 9376

Further reading


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