SLMAP

SLMAP
Identifiers
Aliases	SLMAP, SLAP, sarcolemma associated protein
External IDs	OMIM: 602701 MGI: 1933549 HomoloGene: 31428 GeneCards: SLMAP
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	57,930,003 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	26,534,931 bp[2]
Gene ontology
Molecular function	• GO:0001948 protein binding;
Cellular component	• smooth endoplasmic reticulum; • cytoplasm; • integral component of membrane; • sarcolemma; • cell membrane; • integral component of plasma membrane; • cytoskeleton; • membrane; • microtubule organizing center;
Biological process	• muscle contraction; • protein localization to plasma membrane; • regulation of membrane depolarization during cardiac muscle cell action potential; • regulation of sodium ion transmembrane transport; • regulation of voltage-gated sodium channel activity;
	Sources:Amigo / QuickGO
Orthologs
	7871
	83997
	ENSG00000163681
	ENSMUSG00000021870
	Q14BN4
	Q3URD3
NM_001304420; NM_001304421; NM_001304422; NM_001304423; NM_001311178;
	NM_001311179; NM_007159; NM_001377538; NM_001377539; NM_001377540; NM_001377541; NM_001377542; NM_001377545; NM_001377549; NM_001377551; NM_001377552; NM_001377555; NM_001377557; NM_001377559; NM_001377562; NM_001377921; NM_001377922; NM_001377923; NM_001377924; NM_001377925; NM_001377926; NM_001377927; NM_001377928
	NM_032008; NM_001310445; NM_001347494
NP_001291349; NP_001291350; NP_001291351; NP_001291352; NP_001298107;
	NP_001298108; NP_009090
	NP_001297374; NP_001334423; NP_114397
	Wikidata
View/Edit Human	View/Edit Mouse

Sarcolemmal membrane-associated protein is a protein that in humans is encoded by the SLMAP gene.[5][6][7]

Interactions

SLMAP has been shown to interact with STK24.[8][9]

References

GRCh38: Ensembl release 89: ENSG00000163681 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021870 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wigle JT, Demchyshyn L, Pratt MA, Staines WA, Salih M, Tuana BS (December 19, 1997). "Molecular cloning, expression, and chromosomal assignment of sarcolemmal-associated proteins. A family of acidic amphipathic alpha-helical proteins associated with the membrane". J. Biol. Chem. 272 (51): 32384–94. doi:10.1074/jbc.272.51.32384. PMID 9405447.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
"Entrez Gene: SLMAP sarcolemma associated protein".
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Wielowieyski PA, Sevinc S, Guzzo R, Salih M, Wigle JT, Tuana BS (2000). "Alternative splicing, expression, and genomic structure of the 3' region of the gene encoding the sarcolemmal-associated proteins (SLAPs) defines a novel class of coiled-coil tail-anchored membrane proteins". J. Biol. Chem. 275 (49): 38474–81. doi:10.1074/jbc.M007682200. PMID 10986292.
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163681 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021870 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9405447-5] Wigle JT, Demchyshyn L, Pratt MA, Staines WA, Salih M, Tuana BS (December 19, 1997). "Molecular cloning, expression, and chromosomal assignment of sarcolemmal-associated proteins. A family of acidic amphipathic alpha-helical proteins associated with the membrane". J. Biol. Chem. 272 (51): 32384–94. doi:10.1074/jbc.272.51.32384. PMID 9405447.

[pmid11042152-6] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

[entrez-7] "Entrez Gene: SLMAP sarcolemma associated protein".

[pmid17353931-8] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid18782753-9] Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

SLMAP

Interactions

References

Further reading