SMCR7L

MIEF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NXT, 4NXU, 4NXV, 4NXW, 4NXX
Identifiers
Aliases	MIEF1, HSU79252, MID51, SMCR7L, dJ1104E15.3, mitochondrial elongation factor 1, AltMIEF1-MP
External IDs	OMIM: 615497 MGI: 2146020 HomoloGene: 10374 GeneCards: MIEF1
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	39,518,132 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	80,253,371 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • ADP binding; • GO:0001948 protein binding; • GDP binding; • identical protein binding;
Cellular component	• integral component of membrane; • mitochondrial outer membrane; • peroxisome; • membrane; • mitochondrion; • mitochondrial matrix; • mitochondrial large ribosomal subunit;
Biological process	• mitochondrial fusion; • positive regulation of mitochondrial fission; • mitochondrial fission; • positive regulation of protein targeting to membrane; • regulation of translation; • ribosome biogenesis; • positive regulation of mitochondrial translation;
	Sources:Amigo / QuickGO
Orthologs
	54471
	239555
	ENSG00000100335
	ENSMUSG00000022412
	L0R8F8
	Q8BGV8
	NM_001304564; NM_013298; NM_019008
	NM_178719; NM_001357659; NM_001357660
	NP_001291493; NP_061881
	NP_848834; NP_001344588; NP_001344589
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial dynamic protein MID51 (MID51) also known as mitochondrial elongation factor 1 (MIEF1) or Smith-Magenis syndrome chromosome region candidate gene 7 protein-like (SMCR7L) is a protein that in humans is encoded by the SMCR7L gene.[5][6][7]

Function

The SMCR7L gene codes for a protein that has been called MiD51/MIEF1 and shown to regulate mitochondrial fission by interacting with the proteins Drp1 and FIS1.[8]

References

GRCh38: Ensembl release 89: ENSG00000100335 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022412 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wiemann S; Weil B; Wellenreuther R; Gassenhuber J; Glassl S; Ansorge W; Bocher M; Blocker H; Bauersachs S; Blum H; Lauber J; Dusterhoft A; Beyer A; Kohrer K; Strack N; Mewes HW; Ottenwalder B; Obermaier B; Tampe J; Heubner D; Wambutt R; Korn B; Klein M; Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Andersson B; Wentland MA; Ricafrente JY; Liu W; Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
"Entrez Gene: SMCR7L Smith-Magenis syndrome chromosome region, candidate 7-like".
Dikov, D.; Reichert, A. S. (2011). "How to split up: Lessons from mitochondria". The EMBO Journal. 30 (14): 2751–2753. doi:10.1038/emboj.2011.219. PMC 3160261. PMID 21772324.

Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Hartley JL; Temple GF; Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100335 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022412 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S; Weil B; Wellenreuther R; Gassenhuber J; Glassl S; Ansorge W; Bocher M; Blocker H; Bauersachs S; Blum H; Lauber J; Dusterhoft A; Beyer A; Kohrer K; Strack N; Mewes HW; Ottenwalder B; Obermaier B; Tampe J; Heubner D; Wambutt R; Korn B; Klein M; Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[pmid8619474-6] Andersson B; Wentland MA; Ricafrente JY; Liu W; Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[entrez-7] "Entrez Gene: SMCR7L Smith-Magenis syndrome chromosome region, candidate 7-like".

[8] Dikov, D.; Reichert, A. S. (2011). "How to split up: Lessons from mitochondria". The EMBO Journal. 30 (14): 2751–2753. doi:10.1038/emboj.2011.219. PMC 3160261. PMID 21772324.

SMCR7L

Function

References

Further reading