SMURF1

E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene.[5][6]

SMURF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSMURF1, SMAD specific E3 ubiquitin protein ligase 1
External IDsOMIM: 605568 MGI: 1923038 HomoloGene: 10712 GeneCards: SMURF1
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.1Start99,027,438 bp[1]
End99,144,100 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57154

75788

Ensembl

ENSG00000284126
ENSG00000198742

ENSMUSG00000038780

UniProt

Q9HCE7

Q9CUN6

RefSeq (mRNA)

NM_001199847
NM_020429
NM_181349

NM_001038627
NM_029438

RefSeq (protein)

NP_001186776
NP_065162
NP_851994

NP_001033716
NP_083714

Location (UCSC)Chr 7: 99.03 – 99.14 MbChr 5: 144.88 – 144.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.[6]

Interactions

SMURF1 has been shown to interact with:

References

  1. ENSG00000198742 GRCh38: Ensembl release 89: ENSG00000284126, ENSG00000198742 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038780 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH (Sep 1999). "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation". Nature. 400 (6745): 687–93. doi:10.1038/23293. PMID 10458166. S2CID 204995261.
  6. "Entrez Gene: SMURF1 SMAD specific E3 ubiquitin protein ligase 1".
  7. Yamaguchi K, Ohara O, Ando A, Nagase T (Apr 2008). "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. doi:10.1515/BC.2008.036. PMID 18208356. S2CID 27505034.
  8. Lu K, Yin X, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L, He F (Aug 2008). "Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1". Nat. Cell Biol. 10 (8): 994–1002. doi:10.1038/ncb1760. PMID 18641638. S2CID 19216909.
  9. Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T (Dec 2008). "Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells". J. Biol. Chem. 283 (51): 35660–7. doi:10.1074/jbc.M710496200. PMID 18927080.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9HCE7 (E3 ubiquitin-protein ligase SMURF1) at the PDBe-KB.
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