SPINK2

SPINK2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2JXD
Identifiers
Aliases	SPINK2, HUSI-II, serine peptidase inhibitor, Kazal type 2, SPGF29, serine peptidase inhibitor Kazal type 2
External IDs	OMIM: 605753 HomoloGene: 77717 GeneCards: SPINK2
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	56,821,742 bp[1]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• peptidase inhibitor activity; • endopeptidase inhibitor activity; • GO:0001948 protein binding; • serine-type endopeptidase inhibitor activity;
Cellular component	• extracellular region; • Acrosome; • extracellular; • cytoplasmic vesicle;
Biological process	• regulation of acrosome reaction; • negative regulation of peptidase activity; • negative regulation of serine-type endopeptidase activity; • spermatogenesis; • acrosome assembly; • spermatid development;
	Sources:Amigo / QuickGO
Orthologs
	6691
	n/a
	ENSG00000128040
	n/a
	P20155
	n/a
NM_001271718; NM_001271719; NM_001271720; NM_001271721; NM_001271722;
	NM_021114
	n/a
NP_001258647; NP_001258648; NP_001258649; NP_001258650; NP_001258651;
	NP_066937
	n/a
	Wikidata
View/Edit Human

Serine protease inhibitor Kazal-type 2 also known as acrosin-trypsin inhibitor is a protein that in humans is encoded by the SPINK2 gene.[3][4]

References

GRCh38: Ensembl release 89: ENSG00000128040 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Moritz A, Grzeschik KH, Wingender E, Fink E (Mar 1993). "Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II)". Gene. 123 (2): 277–81. doi:10.1016/0378-1119(93)90138-S. PMID 8428671.
"Entrez Gene: SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)".

[1]

Wapenaar MC, Monsuur AJ, Poell J, et al. (2007). "The SPINK gene family and celiac disease susceptibility". Immunogenetics. 59 (5): 349–57. doi:10.1007/s00251-007-0199-5. PMC 1914236. PMID 17333166.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rockett JC, Patrizio P, Schmid JE, et al. (2004). "Gene expression patterns associated with infertility in humans and rodent models". Mutat. Res. 549 (1–2): 225–40. doi:10.1016/j.mrfmmm.2003.11.017. PMID 15120973.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fink E, Hehlein-Fink C, Eulitz M (1990). "Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones" (PDF). FEBS Lett. 270 (1–2): 222–4. doi:10.1016/0014-5793(90)81273-Q. PMID 2226783. S2CID 1068212.
Collins J, Taube W, Fink E, et al. (1992). "Variants of human seminal acrosin inhibitor (HUSI-II) which inhibit human leukocyte elastase". Biomed. Biochim. Acta. 50 (4–6): 683–5. PMID 1801743.
Möritz A, Lilja H, Fink E (1991). "Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II)". FEBS Lett. 278 (1): 127–30. doi:10.1016/0014-5793(91)80099-O. PMID 1704312. S2CID 34332531.
Dietl T, Kruck J, Schill WB, Fritz H (1977). "Localization of seminal plasma proteinase inhibitors in human spermatozoa as revealed by the indirect immunofluorescence technique". Hoppe-Seyler's Z. Physiol. Chem. 357 (10): 1333–7. doi:10.1515/bchm2.1976.357.2.1333. PMID 791787.

Lee B, Park I, Jin S, Choi H, Kwon JT, Kim J, Jeong J, Cho BN, Eddy EM, Cho C (2011). "Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes". J. Biol. Chem. 286 (33): 29108–17. doi:10.1074/jbc.M111.244905. PMC 3190718. PMID 21705336.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128040 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8428671-3] Moritz A, Grzeschik KH, Wingender E, Fink E (Mar 1993). "Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II)". Gene. 123 (2): 277–81. doi:10.1016/0378-1119(93)90138-S. PMID 8428671.

[entrez-4] "Entrez Gene: SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)".

[5] Lee B, Park I, Jin S, Choi H, Kwon JT, Kim J, Jeong J, Cho BN, Eddy EM, Cho C (2011). "Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes". J. Biol. Chem. 286 (33): 29108–17. doi:10.1074/jbc.M111.244905. PMC 3190718. PMID 21705336.

SPINK2

See also

References

Further reading