SPINT1

Kunitz-type protease inhibitor 1 is an enzyme that in humans is encoded by the SPINT1 gene.[5]

SPINT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPINT1, HAI, HAI1, MANSC2, serine peptidase inhibitor, Kunitz type 1
External IDsOMIM: 605123 MGI: 1338033 HomoloGene: 9653 GeneCards: SPINT1
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q15.1Start40,844,018 bp[1]
End40,858,207 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6692

20732

Ensembl

ENSG00000166145

ENSMUSG00000027315

UniProt

O43278

Q9R097

RefSeq (mRNA)

NM_001032367
NM_003710
NM_181642

NM_016907

RefSeq (protein)

NP_001027539
NP_003701
NP_857593

NP_058603

Location (UCSC)Chr 15: 40.84 – 40.86 MbChr 2: 119.24 – 119.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000166145 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027315 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SPINT1 serine peptidase inhibitor, Kunitz type 1".

Further reading

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