SS18L1

SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.[5]

SS18L1
Identifiers
AliasesSS18L1, CREST, LP2261, nBAF chromatin remodeling complex subunit, SS18L1 subunit of BAF chromatin remodeling complex
External IDsOMIM: 606472 MGI: 2444061 HomoloGene: 9191 GeneCards: SS18L1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.33Start62,143,769 bp[1]
End62,182,514 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

26039

269397

Ensembl

ENSG00000184402

ENSMUSG00000039086

UniProt

O75177

Q8BW22

RefSeq (mRNA)

NM_001301778
NM_015558
NM_198935

NM_178750

RefSeq (protein)

NP_001288707
NP_945173

NP_848865

Location (UCSC)Chr 20: 62.14 – 62.18 MbChr 2: 180.04 – 180.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene is fused in-frame to the 3-prime end of the SSX1, SSX2, or SSX4 gene. The SS18L1 gene is homologous to SS18.[5]

Interactions

SS18L1 has been shown to interact with CREB-binding protein.[6] Biochemical pull down assays reveal SS18L1 to interact with several components of the human SWI/SNF chromatin remodeling complex.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000184402 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000039086 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1".
  6. Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A (January 2004). "Dendrite development regulated by CREST, a calcium-regulated transcriptional activator". Science. 303 (5655): 197–202. Bibcode:2004Sci...303..197A. doi:10.1126/science.1089845. PMID 14716005. S2CID 20879721.
  7. Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE. 7 (3): e33834. Bibcode:2012PLoSO...733834M. doi:10.1371/journal.pone.0033834. PMC 3307773. PMID 22442726.

Further reading


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