SSR4

Translocon-associated protein subunit delta is a protein that in humans is encoded by the SSR4 gene.[5][6]

SSR4
Identifiers
AliasesSSR4, TRAPD, CDG1Y, signal sequence receptor subunit 4
External IDsOMIM: 300090 MGI: 1099464 HomoloGene: 4573 GeneCards: SSR4
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq28Start153,793,516 bp[1]
End153,798,499 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6748

20832

Ensembl

ENSG00000180879

ENSMUSG00000002014

UniProt

P51571

Q62186

RefSeq (mRNA)

NM_001204526
NM_001204527
NM_006280

NM_001166480
NM_009279
NM_001358212
NM_001358213

RefSeq (protein)

NP_001191455
NP_001191456
NP_006271

NP_001159952
NP_033305
NP_001345141
NP_001345142

Location (UCSC)Chr X: 153.79 – 153.8 MbChr X: 73.79 – 73.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them, and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric to the ALD gene. Although alternative splicing of exon 5 has not been detected in human SSR4, transcript variants missing the region homologous to human exon 5 have been detected in both Xenopus laevis and Mus musculus.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000180879 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002014 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
  6. "Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)".

Further reading


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