STAP2

Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene.[5][6][7]

STAP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTAP2, BKS, signal transducing adaptor family member 2
External IDsOMIM: 607881 MGI: 2147039 HomoloGene: 9798 GeneCards: STAP2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start4,324,043 bp[1]
End4,342,786 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55620

106766

Ensembl

ENSG00000178078

ENSMUSG00000038781

UniProt

Q9UGK3

Q8R0L1

RefSeq (mRNA)

NM_001013841
NM_017720

NM_145934

RefSeq (protein)

NP_001013863
NP_060190

NP_666046

Location (UCSC)Chr 19: 4.32 – 4.34 MbChr 17: 56 – 56.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.[7]

Interactions

STAP2 has been shown to interact with PTK6.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000178078 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038781 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mitchell PJ, Sara EA, Crompton MR (Oct 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene. 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. PMID 10980601.
  6. Dehal P, Predki P, Olsen AS, Kobayashi A, Folta P, Lucas S, Land M, Terry A, Ecale Zhou CL, Rash S, Zhang Q, Gordon L, Kim J, Elkin C, Pollard MJ, Richardson P, Rokhsar D, Uberbacher E, Hawkins T, Branscomb E, Stubbs L (Jul 2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
  7. "Entrez Gene: STAP2 signal-transducing adaptor protein-2".

Further reading


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