STK25

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.[5][6][7][8]

STK25
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTK25, SOK1, YSK1, serine/threonine kinase 25
External IDsOMIM: 602255 MGI: 1891699 HomoloGene: 48428 GeneCards: STK25
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q37.3Start241,492,670 bp[1]
End241,509,730 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10494

59041

Ensembl

ENSG00000115694

ENSMUSG00000026277

UniProt

O00506

Q9Z2W1

RefSeq (mRNA)

NM_021537

RefSeq (protein)

NP_067512

Location (UCSC)Chr 2: 241.49 – 241.51 MbChr 1: 93.62 – 93.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

STK25 has been shown to interact with STRN,[9] PDCD10[10] and MOBKL3.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000115694 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026277 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T (Jan 1997). "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway". EMBO J. 15 (17): 4537–46. doi:10.1002/j.1460-2075.1996.tb00831.x. PMC 452183. PMID 8887545.
  6. Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S (Jun 1997). "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways". Oncogene. 14 (17): 2047–57. doi:10.1038/sj.onc.1201043. PMID 9160885.
  7. Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (Mar 2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J Cell Biol. 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC 2172068. PMID 15037601.
  8. "Entrez Gene: STK25 serine/threonine kinase 25 (STE20 homolog, yeast)".
  9. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
  10. Rual JF, Venkatesan K, Hao T, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading


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