STOX1

Storkhead box 1 is a protein in humans that is encoded by the STOX1 gene. [5]

STOX1
Identifiers
Aliases	STOX1, C10orf24, PEE4, storkhead box 1
External IDs	OMIM: 609397 MGI: 2684909 HomoloGene: 17649 GeneCards: STOX1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 68,827,531 bp[1] End 68,895,432 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 62,659,043 bp[2] End 62,726,128 bp[2]
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001948 protein binding Cellular component • cytoplasm • centrosome • nucleoplasm • microtubule organizing center • cell cortex • cytoskeleton • cell nucleus • fibrillar center • nucleolus • cytosol Biological process • positive regulation of protein kinase B signaling • regulation of transcription, DNA-templated • regulation of mitochondrion organization • regulation of mitochondrial DNA metabolic process • positive regulation of epithelial cell proliferation • negative regulation of gene expression • transcription, DNA-templated • positive regulation of peptidyl-serine phosphorylation • positive regulation of cyclin-dependent protein kinase activity • cell division • regulation of mitochondrial membrane potential • positive regulation of gene expression • positive regulation of cell cycle • positive regulation of peptidyl-threonine phosphorylation • positive regulation of cell proliferation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • regulation of response to oxidative stress • regulation of gene expression • inner ear development • positive regulation of G2/M transition of mitotic cell cycle • cell cycle • cellular response to nitrosative stress • positive regulation of otic vesicle morphogenesis • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	219736	216021
Ensembl	ENSG00000165730	ENSMUSG00000036923
UniProt	Q6ZVD7	B2RQL2
RefSeq (mRNA)	NM_001130159 NM_001130160 NM_001130161 NM_001130162 NM_152709	NM_001033260 NM_001364705
RefSeq (protein)	NP_001123631 NP_001123632 NP_001123633 NP_689922	NP_001028432 NP_001351634
Location (UCSC)	Chr 10: 68.83 – 68.9 Mb	Chr 10: 62.66 – 62.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].