STT3B

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit STT3B is an enzyme that in humans is encoded by the STT3B gene.[5][6][7]

STT3B
Identifiers
AliasesSTT3B, CDG1X, SIMP, STT3-B, catalytic subunit of the oligosaccharyltransferase complex, STT3 oligosaccharyltransferase complex catalytic subunit B
External IDsOMIM: 608605 MGI: 1915542 HomoloGene: 7387 GeneCards: STT3B
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p23Start31,532,638 bp[1]
End31,637,616 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

201595

68292

Ensembl

ENSG00000163527

ENSMUSG00000032437

UniProt

Q8TCJ2

Q3TDQ1

RefSeq (mRNA)

NM_178862

NM_024222

RefSeq (protein)

NP_849193

NP_077184

Location (UCSC)Chr 3: 31.53 – 31.64 MbChr 9: 115.24 – 115.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The STT3B protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1 (MIM 601134), STT3B is homologous to yeast STT3, an oligosaccharyltransferase essential for cell proliferation.[8][7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000163527 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032437 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (July 2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Molecular Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
  6. McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.
  7. "Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)".
  8. McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. Springer Science and Business Media LLC. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.

Further reading

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