SYBL1

Synaptobrevin-like protein 1 (SYBL1), also known as vesicle-associated membrane protein 7 (VAMP7), is a protein that in humans is encoded by the VAMP7, or SYBL1, gene.[4][5][6]

VAMP7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVAMP7, SYBL1, TI-VAMP, TIVAMP, VAMP-7, vesicle associated membrane protein 7
External IDsOMIM: 300053 MGI: 1096399 HomoloGene: 4121 GeneCards: VAMP7
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq28 and Yq12Start155,881,345 bp[1]
End155,943,769 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6845

20955

Ensembl

ENSG00000124333

ENSMUSG00000051412

UniProt

P51809

P70280

RefSeq (mRNA)

NM_001145149
NM_001185183
NM_005638

NM_001302138
NM_011515

RefSeq (protein)

NP_001138621
NP_001172112
NP_005629

NP_001289067
NP_035645
NP_001346080

Location (UCSC)Chr X: 155.88 – 155.94 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

SYBL1 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. SYBL1 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.[6]

Interactions

SYBL1 has been shown to interact with SNAP23[7][8] and AP3D1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000124333 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. D'Esposito M, Ciccodicola A, Gianfrancesco F, Esposito T, Flagiello L, Mazzarella R, Schlessinger D, D'Urso M (Jul 1996). "A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation". Nat. Genet. 13 (2): 227–9. doi:10.1038/ng0696-227. PMID 8640232.
  5. Filippini F, Rossi V, Galli T, Budillon A, D'Urso M, D'Esposito M (Jul 2001). "Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain". Trends Biochem. Sci. 26 (7): 407–9. doi:10.1016/S0968-0004(01)01861-8. PMID 11440841.
  6. "Entrez Gene: SYBL1 synaptobrevin-like 1".
  7. Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (Jul 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
  8. Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D (Jun 1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell. 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P51809 (Vesicle-associated membrane protein 7) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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