Saccharopolyspora erythraea

Saccharopolyspora erythraea, formerly known as Streptomyces erythraeus,[1] is a species of actinomycete bacteria within the genus Saccharopolyspora.

Saccharopolyspora erythraea
Scientific classification
Kingdom:
Phylum:
Class:
Actinobacteria
Subclass:
Order:
Family:
Genus:
Species:
S. erythraea
Binomial name
Saccharopolyspora erythraea
Synonyms

Saccharopolyspora erythrea (lapsus)
Streptomyces erythraeus

Saccharopolyspora erythraea produces the macrolide antibiotic erythromycin.[2] Cytochrome P450 eryF (CYP107A1) originally from the bacterium is responsible for the biosynthesis of the antibiotic by C6-hydroxylation of the macrolide 6-deoxyerythronolide B.[3][4]

Small non-coding RNAs have been suggested to be involved in regulation of the secondary metabolite biosynthesis.[5]

References

  1. "Transfer of the Type Strain of Streptomyces erythraeus (Waksman 1923) Waksman and Henrici 1948 to the Genus Saccharopolyspora Lacey and Goodfellow 1975 as Saccharopolyspora erythraea sp. nov., and Designation of a Neotype Strain for Streptomyces erythraeus -- Labeda 37 (1): 19 -- International Journal of Systematic Bacteriology".
  2. Oliynyk, Markiyan; Samborskyy, Markiyan; Lester, John B.; Mironenko, Tatiana; Scott, Nataliya; Dickens, Shilo; Haydock, Stephen F.; Leadlay, Peter F. (2007). "Complete genome sequence of the erythromycin-producing bacterium : Saccharopolyspora erythraea: NRRL23338". Nature Biotechnology. 25 (4): 447–453. doi:10.1038/nbt1297. PMID 17369815.
  3. Cupp-Vickery, JR; Poulos, TL (February 1995). "Structure of cytochrome P450eryF involved in erythromycin biosynthesis". Nature Structural Biology. 2 (2): 144–53. doi:10.1038/nsb0295-144. PMID 7749919.
  4. Harris, DL (20 September 2002). "Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450eryF". Journal of Inorganic Biochemistry. 91 (4): 568–85. doi:10.1016/s0162-0134(02)00477-4. PMID 12237223.
  5. Liu, Wei-Bing; Shi, Yang; Yao, Li-Li; Zhou, Ying; Ye, Bang-Ce (2013-01-01). "Prediction and characterization of small non-coding RNAs related to secondary metabolites in Saccharopolyspora erythraea". PLOS ONE. 8 (11): e80676. Bibcode:2013PLoSO...880676L. doi:10.1371/journal.pone.0080676. ISSN 1932-6203. PMC 3827479. PMID 24236194.


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