Sacubitrilat

Sacubitrilat
Clinical data
Other names	LBQ657
ATC code	none;
Identifiers
	IUPAC name (2R,4S)-5-(4-Biphenylyl)-4-[(3-carboxypropanoyl)amino]-2-methylpentanoic acid;
CAS Number	149709-44-4;
PubChem CID	10430040;
ChemSpider	8605468;
UNII	SPI5PBF81S;
ChEMBL	ChEMBL417007;
PDB ligand	6LD (PDBe, RCSB PDB);
Chemical and physical data
Formula	C22H25NO5
Molar mass	383.444 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H](C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O)C(=O)O;
	InChI InChI=1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1; Key:DOBNVUFHFMVMDB-BEFAXECRSA-N;

Sacubitrilat (INN; or LBQ657) is the active metabolite of the antihypertensive drug sacubitril,[1] which is used in the treatment of heart failure.[2]

References

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