Secobarbital/brallobarbital/hydroxyzine

Secobarbital/brallobarbital/hydroxyzine was a combination tablet containing 50 mg brallobarbital, 150 mg secobarbital and 50 mg hydroxyzine[1] that was used as a sedative. It was sold under the brand name Vesparax. This drug has been withdrawn from the market in most countries.

Secobarbital/brallobarbital/hydroxyzine
Combination of
BrallobarbitalBarbiturate
SecobarbitalBarbiturate
HydroxyzineAntihistamine
Clinical data
Trade namesVesparax

Hydroxyzine and secobarbital lengthen the half-life of brallobarbital. Because of this long half-life, it has symptoms resembling a hangover on the next day.[2][3]

Jimi Hendrix was under the influence of Vesparax when he died of asphyxia due to aspiration of vomit on 18 September 1970.[4]

References
  1. Lhermann J (March 1964). "[Clinical Application of a New Very Active Hypnotic Associating Sodium Secobarbital, Calcium Brallobarbital and Hydroxyzine (Uc-8130)]". Gazette Médicale de France. 71: 961–2. PMID 14142825.
  2. Yih TD, Rossum JM (June 1976). "Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 6 (6): 355–62. doi:10.3109/00498257609151647. PMID 969563.
  3. Fischbach R (1983). "Efficacy and safety of midazolam and vesparax in treatment of sleep disorders". British Journal of Clinical Pharmacology. 16 Suppl 1: 167S–171S. doi:10.1111/j.1365-2125.1983.tb02290.x. PMC 1428085. PMID 6138072.
  4. Brown T (1997). Jimi Hendrix: The Final Days. Omnibus Press. ISBN 978-0-7119-5238-6.

Further reading
  • Sticht G, Käferstein H (1980). "[Results of toxicological investigations on vesparax-poisonings (author's transl)]". Zeitschrift für Rechtsmedizin. Journal of Legal Medicine. 85 (3): 169–75. doi:10.1007/bf02116316. PMID 7415572.
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